Polygenic Score (PGS) ID: PGS005231

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: June 16, 2025
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Score Details

Score Construction
PGS Name GRS142_CAD
Development Method
Name Genome-wide significant SNPs
Parameters r2>0.6
Variants
Original Genome Build NR
Number of Variants 142
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000738
Citation (link to publication) Severance LM et al. JACC Cardiovasc Imaging (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Not Reported: 100%
296,525 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • African
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST005194
Europe PMC: 29212778
 296,525 individuals Not reported NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022660 PSS012050|
Multi-ancestry (including European)|
8,587 individuals
 PGP000738 |
Severance LM et al. JACC Cardiovasc Imaging (2021)
 Reported Trait: coronary artery calcium OR: 1.33 [1.26, 1.4] — — age, sex —
PPM022661 PSS012049|
Multi-ancestry (including European)|
6,660 individuals
 PGP000738 |
Severance LM et al. JACC Cardiovasc Imaging (2021)
 Reported Trait: coronary artery calcium — — Odds ratio (OR, high vs low tertile): 2.68 age, sex, number of traditional risk factors, family history —
PPM022662 PSS012049|
Multi-ancestry (including European)|
6,660 individuals
 PGP000738 |
Severance LM et al. JACC Cardiovasc Imaging (2021)
 Reported Trait: coronary artery calcium with family history of an event — — Odds ratio (OR, high vs low tertile): 2.44 age, sex, number of traditional risk factors —
PPM022663 PSS012049|
Multi-ancestry (including European)|
6,660 individuals
 PGP000738 |
Severance LM et al. JACC Cardiovasc Imaging (2021)
 Reported Trait: coronary artery calcium without family history of an event — — Odds ratio (OR, high vs low tertile): 2.89 age, sex, number of traditional risk factors —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012049 — — 2,647 individuals — European — MESA —
PSS012049 — — 1,834 individuals — African American or Afro-Caribbean — MESA —
PSS012049 — — 2,179 individuals — East Asian, Hispanic or Latin American — MESA —
PSS012050 — — 3,898 individuals — European — CARDIA, MESA —
PSS012050 — — 2,510 individuals — African American or Afro-Caribbean — CARDIA, MESA —
PSS012050 — — 2,179 individuals — East Asian, Hispanic or Latin American — MESA —