PGS Publication: PGP000738

Publication Information (EuropePMC)
Title Targeted Coronary Artery Calcium Screening in High-Risk Younger Individuals Using Consumer Genetic Screening Results.
PubMed ID 33454274(Europe PMC)
doi 10.1016/j.jcmg.2020.11.013
Publication Date Jan. 13, 2021
Journal JACC Cardiovasc Imaging
Author(s) Severance LM, Carter H, Contijoch FJ, McVeigh ER.
Released in PGS Catalog: June 16, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
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Multi-ancestry (excluding European)
African
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South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005231
(GRS142_CAD)
 PGP000738 |
Severance LM et al. JACC Cardiovasc Imaging (2021)
 Coronary artery disease coronary artery disease 142
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005231/ScoringFiles/PGS005231.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022660 PGS005231
(GRS142_CAD)
 PSS012050|
Multi-ancestry (including European)|
8,587 individuals
 PGP000738 |
Severance LM et al. JACC Cardiovasc Imaging (2021)
 Reported Trait: coronary artery calcium OR: 1.33 [1.26, 1.4] — — age, sex —
PPM022661 PGS005231
(GRS142_CAD)
 PSS012049|
Multi-ancestry (including European)|
6,660 individuals
 PGP000738 |
Severance LM et al. JACC Cardiovasc Imaging (2021)
 Reported Trait: coronary artery calcium — — Odds ratio (OR, high vs low tertile): 2.68 age, sex, number of traditional risk factors, family history —
PPM022662 PGS005231
(GRS142_CAD)
 PSS012049|
Multi-ancestry (including European)|
6,660 individuals
 PGP000738 |
Severance LM et al. JACC Cardiovasc Imaging (2021)
 Reported Trait: coronary artery calcium with family history of an event — — Odds ratio (OR, high vs low tertile): 2.44 age, sex, number of traditional risk factors —
PPM022663 PGS005231
(GRS142_CAD)
 PSS012049|
Multi-ancestry (including European)|
6,660 individuals
 PGP000738 |
Severance LM et al. JACC Cardiovasc Imaging (2021)
 Reported Trait: coronary artery calcium without family history of an event — — Odds ratio (OR, high vs low tertile): 2.89 age, sex, number of traditional risk factors —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012049 — — 2,647 individuals — European — MESA —
PSS012049 — — 1,834 individuals — African American or Afro-Caribbean — MESA —
PSS012049 — — 2,179 individuals — East Asian, Hispanic or Latin American — MESA —
PSS012050 — — 3,898 individuals — European — CARDIA, MESA —
PSS012050 — — 2,510 individuals — African American or Afro-Caribbean — CARDIA, MESA —
PSS012050 — — 2,179 individuals — East Asian, Hispanic or Latin American — MESA —