Polygenic Score (PGS) ID: PGS005236

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disorder (MONDO_0005010)
Released in PGS Catalog: July 24, 2025
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name CAD_AnnoPred
Development Method
Name AnnoPred
Parameters tier 2; p-0.003; pT
Variants
Original Genome Build hg19
Number of Variants 2,994,055
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000740
Citation (link to publication) Hu J et al. PLoS Comput Biol (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
184,305 individuals (100%)
Score Development/Training
European: 100%
81,581 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 26343387
[
  • 60,801 cases
  • , 123,504 controls
]
 European CARDIoGRAMplusC4D
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 7,384 cases
  • , 74,197 controls
]
 European UKB — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022669 PSS012052|
European Ancestry|
407,903 individuals
 PGP000740 |
Hu J et al. PLoS Comput Biol (2025)
 Reported Trait: Coronary artery disease HR: 1.72 — — — —
PPM030662 PSS012227|
European Ancestry|
18,732 individuals
 PGP000794 |
Ye Y et al. Front Bioinform (2024)
|Ext.		 Reported Trait: CAD — AUROC: 0.597 [0.571, 0.623] AUROC of meta-PRS (PRS_CAD + PRS_IS + PRS_HF) for CAD: 0.598 [0.573, 0.625] PRS_CAD (PGS Catalog ID: PGS005236) + PRS_IS (this paper) + PRS_HF (this paper) combined to derive meta-PRS The meta-PRS was constructed by combining PRS_CAD, PRS_IS, and PRS_HF at the PRS level using weights described in the study. Implementation details are available at: https://github.com/JqiHu/meta-PRS-CVD
PPM030663 PSS012227|
European Ancestry|
18,732 individuals
 PGP000794 |
Ye Y et al. Front Bioinform (2024)
|Ext.		 Reported Trait: Late CAD — AUROC: 0.549 [0.525, 0.573] AUROC of meta-PRS (PRS_CAD + PRS_IS + PRS_HF) for late CAD: 0.557 [0.532, 0.581] PRS_CAD (PGS Catalog ID: PGS005236) + PRS_IS (this paper) + PRS_HF (this paper) combined to derive meta-PRS The meta-PRS was constructed by combining PRS_CAD, PRS_IS, and PRS_HF at the PRS level using weights described in the study. Implementation details are available at: https://github.com/JqiHu/meta-PRS-CVD
PPM030664 PSS012227|
European Ancestry|
18,732 individuals
 PGP000794 |
Ye Y et al. Front Bioinform (2024)
|Ext.		 Reported Trait: Early CAD — AUROC: 0.604 [0.551, 0.657] AUROC of meta-PRS (PRS_CAD + PRS_IS + PRS_HF) for early CAD: 0.614 [0.561, 0.665] PRS_CAD (PGS Catalog ID: PGS005236) + PRS_IS (this paper) + PRS_HF (this paper) combined to derive meta-PRS The meta-PRS was constructed by combining PRS_CAD, PRS_IS, and PRS_HF at the PRS level using weights described in the study. Implementation details are available at: https://github.com/JqiHu/meta-PRS-CVD

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012052 — —
[
  • 20,411 cases
  • , 387,492 controls
]
 — European — UKB —
PSS012227 — —
[
  • 263 cases
  • , 18,469 controls
]
 — European
(British)		 — UKB —