PGS Publication: PGP000740

Publication Information (EuropePMC)
Title Robust pleiotropy-decomposed polygenic scores identify distinct contributions to elevated coronary artery disease polygenic risk.
PubMed ID 40570042(Europe PMC)
doi 10.1371/journal.pcbi.1013191
Publication Date June 26, 2025
Journal PLoS Comput Biol
Author(s) Hu J, Ye Y, Zhang C, Ruan Y, Natarajan P, Zhao H.
Released in PGS Catalog: July 24, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005236
(CAD_AnnoPred)
 PGP000740 |
Hu J et al. PLoS Comput Biol (2025)
 Coronary artery disease coronary artery disease 2,994,055
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005236/ScoringFiles/PGS005236.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022669 PGS005236
(CAD_AnnoPred)
 PSS012052|
European Ancestry|
407,903 individuals
 PGP000740 |
Hu J et al. PLoS Comput Biol (2025)
 Reported Trait: Coronary artery disease HR: 1.72 — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012052 — —
[
  • 20,411 cases
  • , 387,492 controls
]
 — European — UKB —