Polygenic Score (PGS) ID: PGS005249

Predicted Trait
Reported Trait LDL-C levels
Mapped Trait(s) low density lipoprotein cholesterol measurement (EFO_0004611)
Released in PGS Catalog: July 24, 2025
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Score Details

Score Construction
PGS Name PGS5_QBB_6SNP
Development Method
Name P + T
Parameters LD r2 <= 0.2, P<=5x10^-10
Variants
Original Genome Build GRCh38
Number of Variants 6
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000743
Citation (link to publication) Ismail Umlai UK et al. J Lipid Res (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Greater Middle Eastern: 100%
5,939 individuals (100%)
PGS Evaluation
Greater Middle Eastern: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90565128
Europe PMC: 39909172
 5,939 individuals,
43.51 % Male samples
 Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)		 QBB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022730 PSS012062|
Greater Middle Eastern Ancestry|
7,762 individuals
 PGP000743 |
Ismail Umlai UK et al. J Lipid Res (2025)
 Reported Trait: LDL-C levels — — R²: 0.139 [0.118, 0.16] Age, Gender, Cholesterol treatment, PC1-4 Performance reported as adjusted R2 and with 95% [CI]

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012062 — — 7,762 individuals,
45.09 % Male samples
 Mean = 40.4 years
Sd = 13.4 years		 Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)		 — QBB —