PGS Publication: PGP000743

Publication Information (EuropePMC)
Title A multi-ancestry genome-wide association study and evaluation of polygenic scores of LDL-C levels.
PubMed ID 39909172(Europe PMC)
doi 10.1016/j.jlr.2025.100752
Publication Date Feb. 3, 2025
Journal J Lipid Res
Author(s) Ismail Umlai UK, Toor SM, Al-Sarraj YA, Mohammed S, Al Hail MSH, Ullah E, Kunji K, El-Menyar A, Gomaa M, Jayyousi A, Saad M, Qureshi N, Al Suwaidi JM, Albagha OME.
Released in PGS Catalog: July 24, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005248
(PGS4_QBB_9SNP)
 PGP000743 |
Ismail Umlai UK et al. J Lipid Res (2025)
 LDL-C levels low density lipoprotein cholesterol measurement 9
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005248/ScoringFiles/PGS005248.txt.gz
PGS005249
(PGS5_QBB_6SNP)
 PGP000743 |
Ismail Umlai UK et al. J Lipid Res (2025)
 LDL-C levels low density lipoprotein cholesterol measurement 6
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005249/ScoringFiles/PGS005249.txt.gz
PGS005250
(PGS14_QBB_14SNP)
 PGP000743 |
Ismail Umlai UK et al. J Lipid Res (2025)
 LDL-C levels low density lipoprotein cholesterol measurement 14
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005250/ScoringFiles/PGS005250.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022729 PGS005248
(PGS4_QBB_9SNP)
 PSS012062|
Greater Middle Eastern Ancestry|
7,762 individuals
 PGP000743 |
Ismail Umlai UK et al. J Lipid Res (2025)
 Reported Trait: LDL-C levels — — R²: 0.135 [0.114, 0.156] Age, Gender, Cholesterol treatment, PC1-4 Performance reported as adjusted R2 and with 95% [CI]
PPM022730 PGS005249
(PGS5_QBB_6SNP)
 PSS012062|
Greater Middle Eastern Ancestry|
7,762 individuals
 PGP000743 |
Ismail Umlai UK et al. J Lipid Res (2025)
 Reported Trait: LDL-C levels — — R²: 0.139 [0.118, 0.16] Age, Gender, Cholesterol treatment, PC1-4 Performance reported as adjusted R2 and with 95% [CI]
PPM022731 PGS005250
(PGS14_QBB_14SNP)
 PSS012062|
Greater Middle Eastern Ancestry|
7,762 individuals
 PGP000743 |
Ismail Umlai UK et al. J Lipid Res (2025)
 Reported Trait: LDL-C levels — — R²: 0.134 [0.113, 0.155] Age, Gender, Cholesterol treatment, PC1-4 Performance reported as adjusted R2 and with 95% [CI]

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012062 — — 7,762 individuals,
45.09 % Male samples
 Mean = 40.4 years
Sd = 13.4 years		 Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)		 — QBB —