Polygenic Score (PGS) ID: PGS005253

Predicted Trait
Reported Trait Cardiovascular disease
Mapped Trait(s) cardiovascular disease (EFO_0000319)
Released in PGS Catalog: Aug. 6, 2025
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name CVD_MetaPRS
Development Method
Name MetaPRS
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 3,846,195
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000746
Citation (link to publication) Sun D et al. Genome Med (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 78.2%
East Asian: 12.3%
Multi-ancestry (including European): 8.9%
  • European
  • East Asian
  • Not Reported
African: 0.4%
Additional Diverse Ancestries: 0.09%
Hispanic or Latin American: 0.07%
South Asian: 0.07%
15,549,033 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90132315
Europe PMC: 36474045
 1,378,170 individuals European, East Asian, NR 9 cohorts
  • BBJ
  • ,CARDIoGRAMplusC4D
  • ,EPIC_CAD
  • ,GerMIFS
  • ,HUNT
  • ,MGBB
  • ,Other
  • ,UKB
  • ,deCODE
GWAS Catalog: GCST90018890
Europe PMC: 34594039
 483,078 individuals European BBJ, FinnGen, UKB
GWAS Catalog: GCST90018890
Europe PMC: 34594039
 177,713 individuals East Asian BBJ, FinnGen, UKB
GWAS Catalog: GCST90104535
Europe PMC: 36180795
 20,924 individuals African American or Afro-Caribbean Multiple
GWAS Catalog: GCST90104535
Europe PMC: 36180795
 256,274 individuals East Asian Multiple
GWAS Catalog: GCST90104535
Europe PMC: 36180795
 1,296,908 individuals European Multiple
GWAS Catalog: GCST90104535
Europe PMC: 36180795
 5,326 individuals Hispanic or Latin American Multiple
GWAS Catalog: GCST90104535
Europe PMC: 36180795
 11,134 individuals South Asian Multiple
GWAS Catalog: GCST90018870
Europe PMC: 34594039
 473,513 individuals European BBJ, FinnGen, UKB
GWAS Catalog: GCST90018870
Europe PMC: 34594039
 153,478 individuals East Asian BBJ, FinnGen, UKB
GWAS Catalog: GCST006061
Europe PMC: 29892015
 537,409 individuals European NR
GWAS Catalog: GCST006061
Europe PMC: 29892015
 36,792 individuals East Asian
(Japanese)		 NR
GWAS Catalog: GCST006061
Europe PMC: 29892015
 8,967 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST006061
Europe PMC: 29892015
 5,022 individuals Hispanic or Latin American NR
GWAS Catalog: GCST90162626
Europe PMC: 36376295
 26,674 individuals African unspecified 7 cohorts
  • BioMe
  • ,FinnGen
  • ,MyCode
  • ,Other
  • ,PMB
  • ,UKB
  • ,eMERGE
GWAS Catalog: GCST90162626
Europe PMC: 36376295
 14,387 individuals Other admixed ancestry 7 cohorts
  • BioMe
  • ,FinnGen
  • ,MyCode
  • ,Other
  • ,PMB
  • ,UKB
  • ,eMERGE
GWAS Catalog: GCST90162626
Europe PMC: 36376295
 257,928 individuals East Asian 7 cohorts
  • BioMe
  • ,FinnGen
  • ,MyCode
  • ,Other
  • ,PMB
  • ,UKB
  • ,eMERGE
GWAS Catalog: GCST90162626
Europe PMC: 36376295
 1,366,492 individuals European 7 cohorts
  • BioMe
  • ,FinnGen
  • ,MyCode
  • ,Other
  • ,PMB
  • ,UKB
  • ,eMERGE
GWAS Catalog: GCST006624
Europe PMC: 30224653
 757,601 individuals European NR
GWAS Catalog: GCST90018752
Europe PMC: 34594039
 145,505 individuals East Asian BBJ
GWAS Catalog: GCST006630
Europe PMC: 30224653
 757,601 individuals European NR
GWAS Catalog: GCST90018732
Europe PMC: 34594039
 145,515 individuals East Asian BBJ
GWAS Catalog: GCST90239664
Europe PMC: 34887591
 1,320,016 individuals European Multiple
GWAS Catalog: GCST90018755
Europe PMC: 34594039
 111,667 individuals East Asian BBJ
GWAS Catalog: GCST90239676
Europe PMC: 34887591
 1,320,016 individuals European Multiple
GWAS Catalog: GCST90018754
Europe PMC: 34594039
 135,808 individuals East Asian BBJ
GWAS Catalog: GCST90239658
Europe PMC: 34887591
 1,320,016 individuals European Multiple
GWAS Catalog: GCST90018741
Europe PMC: 34594039
 72,866 individuals East Asian BBJ
GWAS Catalog: GCST90239652
Europe PMC: 34887591
 1,320,016 individuals European Multiple
GWAS Catalog: GCST90018736
Europe PMC: 34594039
 74,970 individuals East Asian BBJ
GWAS Catalog: GCST009379
Europe PMC: 30297969
 898,130 individuals European NR
GWAS Catalog: GCST90013693
Europe PMC: 32514122
 210,865 individuals East Asian BBJ
GWAS Catalog: GCST90018955
Europe PMC: 34594039
 314,916 individuals European BBJ, UKB
GWAS Catalog: GCST90018955
Europe PMC: 34594039
 133,336 individuals East Asian BBJ, UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022736 PSS012067|
East Asian Ancestry|
72,149 individuals
 PGP000746 |
Sun D et al. Genome Med (2025)
 Reported Trait: Incident cardiovascular disease HR: 1.2 [1.19, 1.22] — — age, sex, highest education, marital status, top 10 genetic principal components, and genotyping arrays —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012067 ICD-10: I00-I99 Median = 12.1 years
[
  • 17,183 cases
  • , 54,966 controls
]
 — East Asian — CKB —