PGS Publication: PGP000746

Publication Information (EuropePMC)
Title Impact of genetic risk and lifestyles on cardiovascular disease-free and total life expectancy: a cohort study.
PubMed ID 40696436(Europe PMC)
doi 10.1186/s13073-025-01487-9
Publication Date July 22, 2025
Journal Genome Med
Author(s) Sun D, Sun Q, Ding Y, Yu C, Sun D, Pang Y, Pei P, Yang L, Millwood IY, Walters RG, Du H, Zhang J, Schmidt D, Chen J, Chen Z, Li L, Lv J, China Kadoorie Biobank Collaborative Group.
Released in PGS Catalog: Aug. 6, 2025

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005253
(CVD_MetaPRS)
 PGP000746 |
Sun D et al. Genome Med (2025)
 Cardiovascular disease cardiovascular disease 3,846,195
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005253/ScoringFiles/PGS005253.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022736 PGS005253
(CVD_MetaPRS)
 PSS012067|
East Asian Ancestry|
72,149 individuals
 PGP000746 |
Sun D et al. Genome Med (2025)
 Reported Trait: Incident cardiovascular disease HR: 1.2 [1.19, 1.22] — — age, sex, highest education, marital status, top 10 genetic principal components, and genotyping arrays —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012067 ICD-10: I00-I99 Median = 12.1 years
[
  • 17,183 cases
  • , 54,966 controls
]
 — East Asian — CKB —