Polygenic Score (PGS) ID: PGS005280

Predicted Trait
Reported Trait Total IgE
Mapped Trait(s) immunoglobulin E measurement (EFO_0020464)
Released in PGS Catalog: Aug. 6, 2025
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name IgE_GWAS_9260_Japanese_individuals_rev2.EAS
Development Method
Name PRS-CS
Parameters ϕ = 1e-6
Variants
Original Genome Build GRCh37
Number of Variants 970,856
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000752
Citation (link to publication) Sutoh Y et al. Am J Hum Genet (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
9,260 individuals (100%)
Score Development/Training
East Asian: 100%
7,482 individuals (100%)
PGS Evaluation
East Asian: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
9,260 individuals East Asian
(Japanese)		 IMM, ToMMo
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 7,482 individuals,
33.5 % Male samples
 East Asian
(Japanese)		 IMM — Mean = 56.4 years
Sd = 13.2 years		 — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022769 PSS012079|
East Asian Ancestry|
47,766 individuals
 PGP000752 |
Sutoh Y et al. Am J Hum Genet (2025)
 Reported Trait: Total IgE — — Spearman's ρ: 0.174 age, sex, genetic PCs (1-10) The total IgE was subjected to a common logarithmic transformation and adjusted for covariates.
PPM022770 PSS012078|
East Asian Ancestry|
11,698 individuals
 PGP000752 |
Sutoh Y et al. Am J Hum Genet (2025)
 Reported Trait: Total IgE — — Spearman's ρ: 0.189 age, sex, genetic PCs (1-10) The total IgE was subjected to a common logarithmic transformation and adjusted for covariates.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012078 — — 11,698 individuals,
24.4 % Male samples
 Mean = 58.0 years
Sd = 12.9 years		 East Asian
(Japanese)		 — ToMMo —
PSS012079 — — 47,766 individuals,
39.7 % Male samples
 Mean = 60.3 years
Sd = 11.4 years		 East Asian
(Japanese)		 — IMM, ToMMo —