PGS Publication: PGP000752

Publication Information (EuropePMC)
Title Genetic predisposition for immunoglobulin E production explains atopic risk in children: Tohoku Medical Megabank cohort study.
PubMed ID 40695273(Europe PMC)
doi 10.1016/j.ajhg.2025.06.015
Publication Date July 15, 2025
Journal Am J Hum Genet
Author(s) Sutoh Y, Hachiya T, Otsuka-Yamasaki Y, Komaki S, Minabe S, Ohmomo H, Tanno K, Hozawa A, Nakaya N, Noda A, Orui M, Ishikuro M, Obara T, Kuriyama S, Sasaki M, Shimizu A.
Released in PGS Catalog: Aug. 6, 2025

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005280
(IgE_GWAS_9260_Japanese_individuals_rev2.EAS)
 PGP000752 |
Sutoh Y et al. Am J Hum Genet (2025)
 Total IgE immunoglobulin E measurement 970,856
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005280/ScoringFiles/PGS005280.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022769 PGS005280
(IgE_GWAS_9260_Japanese_individuals_rev2.EAS)
 PSS012079|
East Asian Ancestry|
47,766 individuals
 PGP000752 |
Sutoh Y et al. Am J Hum Genet (2025)
 Reported Trait: Total IgE — — Spearman's ρ: 0.174 age, sex, genetic PCs (1-10) The total IgE was subjected to a common logarithmic transformation and adjusted for covariates.
PPM022770 PGS005280
(IgE_GWAS_9260_Japanese_individuals_rev2.EAS)
 PSS012078|
East Asian Ancestry|
11,698 individuals
 PGP000752 |
Sutoh Y et al. Am J Hum Genet (2025)
 Reported Trait: Total IgE — — Spearman's ρ: 0.189 age, sex, genetic PCs (1-10) The total IgE was subjected to a common logarithmic transformation and adjusted for covariates.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012078 — — 11,698 individuals,
24.4 % Male samples
 Mean = 58.0 years
Sd = 12.9 years		 East Asian
(Japanese)		 — ToMMo —
PSS012079 — — 47,766 individuals,
39.7 % Male samples
 Mean = 60.3 years
Sd = 11.4 years		 East Asian
(Japanese)		 — IMM, ToMMo —