Polygenic Score (PGS) ID: PGS005281

Predicted Trait
Reported Trait Height
Mapped Trait(s) body height (OBA_VT0001253)
Released in PGS Catalog: Aug. 6, 2025
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Score Details

Score Construction
PGS Name PRS12111_height
Development Method
Name Genome-wide signoficant SNPs
Parameters NR
Variants
Original Genome Build hg19
Number of Variants 12,111
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000755
Citation (link to publication) Ramírez-Luzuriaga MJ et al. Hum Mol Genet (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 100%
  • European
  • Hispanic or Latin American
  • East Asian
  • African
  • South Asian
5,314,291 individuals (100%)
PGS Evaluation
Additional Diverse Ancestries: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90245848
Europe PMC: 36224396
 5,314,291 individuals European, Hispanic or Latin American, East Asian, African unspecified, South Asian Multiple

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022983 PSS012086|
Additional Diverse Ancestries|
787 individuals
 PGP000755 |
Ramírez-Luzuriaga MJ et al. Hum Mol Genet (2024)
 Reported Trait: Adult height β: 3.6 [3.08, 4.11] — r: 0.44 sex, birth year, maternal diabetes, five genetic principal components and genetic relatedness —
PPM022984 PSS012086|
Additional Diverse Ancestries|
787 individuals
 PGP000755 |
Ramírez-Luzuriaga MJ et al. Hum Mol Genet (2024)
 Reported Trait: Height at take-off β: 2.82 [2.23, 3.41] — r: 0.33 sex, birth year, maternal diabetes, five genetic principal components and genetic relatedness —
PPM022985 PSS012086|
Additional Diverse Ancestries|
787 individuals
 PGP000755 |
Ramírez-Luzuriaga MJ et al. Hum Mol Genet (2024)
 Reported Trait: Height at peak velocity β: 2.88 [2.4, 3.37] — r: 0.4 sex, birth year, maternal diabetes, five genetic principal components and genetic relatedness —
PPM022986 PSS012086|
Additional Diverse Ancestries|
787 individuals
 PGP000755 |
Ramírez-Luzuriaga MJ et al. Hum Mol Genet (2024)
 Reported Trait: Adolescent growth β: 0.84 [0.46, 1.21] — r: 0.16 sex, birth year, maternal diabetes, five genetic principal components and genetic relatedness —
PPM022987 PSS012086|
Additional Diverse Ancestries|
787 individuals
 PGP000755 |
Ramírez-Luzuriaga MJ et al. Hum Mol Genet (2024)
 Reported Trait: Velocity at take-off β: 0.18 [0.12, 0.24] — r: 0.2 sex, birth year, maternal diabetes, five genetic principal components and genetic relatedness —
PPM022988 PSS012086|
Additional Diverse Ancestries|
787 individuals
 PGP000755 |
Ramírez-Luzuriaga MJ et al. Hum Mol Genet (2024)
 Reported Trait: Velocity at peak velocity β: 0.14 [0.05, 0.22] — r: 0.12 sex, birth year, maternal diabetes, five genetic principal components and genetic relatedness —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012086 — — 787 individuals,
38.0 % Male samples
 Mean = 31.9 years
Sd = 9.73 years		 Native American
(American Indian)		 US NR —