PGS Publication: PGP000755

Publication Information (EuropePMC)
Title Novel signals and polygenic score for height are associated with pubertal growth traits in Southwestern American Indians.
PubMed ID 38483351(Europe PMC)
doi 10.1093/hmg/ddae030
Publication Date May 1, 2024
Journal Hum Mol Genet
Author(s) Ramírez-Luzuriaga MJ, Kobes S, Hsueh WC, Baier LJ, Hanson RL.
Released in PGS Catalog: Aug. 6, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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South Asian
Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005281
(PRS12111_height)
 PGP000755 |
Ramírez-Luzuriaga MJ et al. Hum Mol Genet (2024)
 Height body height 12,111
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005281/ScoringFiles/PGS005281.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022983 PGS005281
(PRS12111_height)
 PSS012086|
Additional Diverse Ancestries|
787 individuals
 PGP000755 |
Ramírez-Luzuriaga MJ et al. Hum Mol Genet (2024)
 Reported Trait: Adult height β: 3.6 [3.08, 4.11] — r: 0.44 sex, birth year, maternal diabetes, five genetic principal components and genetic relatedness —
PPM022984 PGS005281
(PRS12111_height)
 PSS012086|
Additional Diverse Ancestries|
787 individuals
 PGP000755 |
Ramírez-Luzuriaga MJ et al. Hum Mol Genet (2024)
 Reported Trait: Height at take-off β: 2.82 [2.23, 3.41] — r: 0.33 sex, birth year, maternal diabetes, five genetic principal components and genetic relatedness —
PPM022985 PGS005281
(PRS12111_height)
 PSS012086|
Additional Diverse Ancestries|
787 individuals
 PGP000755 |
Ramírez-Luzuriaga MJ et al. Hum Mol Genet (2024)
 Reported Trait: Height at peak velocity β: 2.88 [2.4, 3.37] — r: 0.4 sex, birth year, maternal diabetes, five genetic principal components and genetic relatedness —
PPM022986 PGS005281
(PRS12111_height)
 PSS012086|
Additional Diverse Ancestries|
787 individuals
 PGP000755 |
Ramírez-Luzuriaga MJ et al. Hum Mol Genet (2024)
 Reported Trait: Adolescent growth β: 0.84 [0.46, 1.21] — r: 0.16 sex, birth year, maternal diabetes, five genetic principal components and genetic relatedness —
PPM022987 PGS005281
(PRS12111_height)
 PSS012086|
Additional Diverse Ancestries|
787 individuals
 PGP000755 |
Ramírez-Luzuriaga MJ et al. Hum Mol Genet (2024)
 Reported Trait: Velocity at take-off β: 0.18 [0.12, 0.24] — r: 0.2 sex, birth year, maternal diabetes, five genetic principal components and genetic relatedness —
PPM022988 PGS005281
(PRS12111_height)
 PSS012086|
Additional Diverse Ancestries|
787 individuals
 PGP000755 |
Ramírez-Luzuriaga MJ et al. Hum Mol Genet (2024)
 Reported Trait: Velocity at peak velocity β: 0.14 [0.05, 0.22] — r: 0.12 sex, birth year, maternal diabetes, five genetic principal components and genetic relatedness —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012086 — — 787 individuals,
38.0 % Male samples
 Mean = 31.9 years
Sd = 9.73 years		 Native American
(American Indian)		 US NR —