Polygenic Score (PGS) ID: PGS005293

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: Dec. 18, 2025
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Score Details

Score Construction
PGS Name Jorda_CAD_MTAG-PGS_2024
Development Method
Name LDpred2
Parameters Grid method: ρ 0.01; h2SNP 0.0048; sparsity 0.442
Variants
Original Genome Build GRCh38
Number of Variants 1,003,984
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000759
Citation (link to publication) Jordà P et al. NPJ Genom Med (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
310,368 individuals (100%)
Score Development/Training
European: 100%
2,500 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90668074
 310,368 individuals European NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
2,500 individuals European MHI Atrial fibrillation or flutter — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023001 PSS012090|
European Ancestry|
12,677 individuals
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Reported Trait: Prevalent coronary artery disease defined as myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, unstable angina and chronic ischemic heart disease. — AUROC: 0.772 R²: 0.27974 age, sex, four first principal components of genetic ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012090 Atrial fibrillation or flutter — 12,677 individuals — European — MHI —