| Publication Information (EuropePMC) | |
| Title | Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases. |
| PubMed ID | 41022758(Europe PMC) |
| doi | 10.1038/s41525-025-00515-2 |
| Publication Date | Sept. 29, 2025 |
| Journal | NPJ Genom Med |
| Author(s) | Jordà P, Lai Y, Jeuken A, Lemieux Perreault LP, Goulet E, Lahrouchi N, Nozza A, Tanck MW, Guerra P, Cadrin-Tourigny J, de Denus S, Bezzina CR, Lettre G, Busseuil D, Dubé MP, Tardif JC, Tadros R. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS005300 (Jorda_HF_MTAG-PGS_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Heart failure | heart failure | 923,722 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005300/ScoringFiles/PGS005300.txt.gz | |
| PGS005302 (Jorda_HF_MTAG-PGS_males_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Heart failure | heart failure | 923,722 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005302/ScoringFiles/PGS005302.txt.gz | |
| PGS005303 (Jorda_HF_SingleTrait-PGS-inf_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Heart failure | heart failure | 1,042,531 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005303/ScoringFiles/PGS005303.txt.gz |
| PGS005304 (Jorda_HF_SingleTrait-PGS_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Heart failure | heart failure | 1,042,531 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005304/ScoringFiles/PGS005304.txt.gz | |
| PGS005305 (Jorda_HF_SingleTrait-PGS_females_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Heart failure | heart failure | 1,042,531 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005305/ScoringFiles/PGS005305.txt.gz | |
| PGS005306 (Jorda_HF_SingleTrait-PGS_males_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Heart failure | heart failure | 1,042,531 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005306/ScoringFiles/PGS005306.txt.gz | |
| PGS005287 (Jorda_AF_MTAG-PGS_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Atrial fibrillation | atrial fibrillation | 1,016,634 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005287/ScoringFiles/PGS005287.txt.gz | |
| PGS005288 (Jorda_AF_MTAG-PGS_females_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Atrial fibrillation | atrial fibrillation | 1,016,634 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005288/ScoringFiles/PGS005288.txt.gz | |
| PGS005289 (Jorda_AF_MTAG-PGS_males_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Atrial fibrillation | atrial fibrillation | 1,016,634 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005289/ScoringFiles/PGS005289.txt.gz | |
| PGS005290 (Jorda_AF_SingleTrait-PGS_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Atrial fibrillation | atrial fibrillation | 1,045,170 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005290/ScoringFiles/PGS005290.txt.gz | |
| PGS005291 (Jorda_AF_SingleTrait-PGS_females_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Atrial fibrillation | atrial fibrillation | 1,045,170 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005291/ScoringFiles/PGS005291.txt.gz | |
| PGS005292 (Jorda_AF_SingleTrait-PGS_males_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Atrial fibrillation | atrial fibrillation | 1,045,170 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005292/ScoringFiles/PGS005292.txt.gz | |
| PGS005295 (Jorda_CAD_MTAG-PGS_males_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Coronary artery disease | coronary artery disorder | 1,003,984 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005295/ScoringFiles/PGS005295.txt.gz | |
| PGS005296 (Jorda_CAD_SingleTrait-PGS_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Coronary artery disease | coronary artery disorder | 1,042,395 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005296/ScoringFiles/PGS005296.txt.gz | |
| PGS005299 (Jorda_HF_MTAG-PGS-inf_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Heart failure | heart failure | 923,722 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005299/ScoringFiles/PGS005299.txt.gz |
| PGS005297 (Jorda_CAD_SingleTrait-PGS_females_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Coronary artery disease | coronary artery disorder | 1,042,395 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005297/ScoringFiles/PGS005297.txt.gz | |
| PGS005298 (Jorda_CAD_SingleTrait-PGS_males_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Coronary artery disease | coronary artery disorder | 1,042,395 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005298/ScoringFiles/PGS005298.txt.gz | |
| PGS005301 (Jorda_HF_MTAG-PGS_females_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Heart failure | heart failure | 923,722 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005301/ScoringFiles/PGS005301.txt.gz | |
| PGS005293 (Jorda_CAD_MTAG-PGS_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Coronary artery disease | coronary artery disorder | 1,003,984 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005293/ScoringFiles/PGS005293.txt.gz | |
| PGS005294 (Jorda_CAD_MTAG-PGS_females_2024) |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Coronary artery disease | coronary artery disorder | 1,003,984 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005294/ScoringFiles/PGS005294.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM022996 | PGS005288 (Jorda_AF_MTAG-PGS_females_2024) |
PSS012091| European Ancestry| 5,152 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent atrial fibrillation or flutter | — | AUROC: 0.68996 | R²: 0.11543 | age, sex, four first principal components of genetic ancestry | — |
| PPM022997 | PGS005289 (Jorda_AF_MTAG-PGS_males_2024) |
PSS012092| European Ancestry| 7,525 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent atrial fibrillation or flutter | — | AUROC: 0.6813 | R²: 0.12547 | age, sex, four first principal components of genetic ancestry | — |
| PPM022998 | PGS005290 (Jorda_AF_SingleTrait-PGS_2024) |
PSS012090| European Ancestry| 12,677 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent atrial fibrillation or flutter | — | AUROC: 0.703 | R²: 0.14556 | age, sex, four first principal components of genetic ancestry | — |
| PPM022999 | PGS005291 (Jorda_AF_SingleTrait-PGS_females_2024) |
PSS012091| European Ancestry| 5,152 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent atrial fibrillation or flutter | — | AUROC: 0.69331 | R²: 0.11768 | age, sex, four first principal components of genetic ancestry | — |
| PPM023000 | PGS005292 (Jorda_AF_SingleTrait-PGS_males_2024) |
PSS012092| European Ancestry| 7,525 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent atrial fibrillation or flutter | — | AUROC: 0.68445 | R²: 0.12821 | age, sex, four first principal components of genetic ancestry | — |
| PPM023003 | PGS005295 (Jorda_CAD_MTAG-PGS_males_2024) |
PSS012092| European Ancestry| 7,525 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent coronary artery disease defined as myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, unstable angina and chronic ischemic heart disease. | — | AUROC: 0.69218 | R²: 0.15544 | age, sex, four first principal components of genetic ancestry | — |
| PPM023004 | PGS005296 (Jorda_CAD_SingleTrait-PGS_2024) |
PSS012090| European Ancestry| 12,677 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent coronary artery disease defined as myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, unstable angina and chronic ischemic heart disease. | — | AUROC: 0.772 | R²: 0.27809 | age, sex, four first principal components of genetic ancestry | — |
| PPM023005 | PGS005297 (Jorda_CAD_SingleTrait-PGS_females_2024) |
PSS012091| European Ancestry| 5,152 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent coronary artery disease defined as myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, unstable angina and chronic ischemic heart disease. | — | AUROC: 0.68603 | R²: 0.10575 | age, sex, four first principal components of genetic ancestry | — |
| PPM023007 | PGS005299 (Jorda_HF_MTAG-PGS-inf_2024) |
PSS012090| European Ancestry| 12,677 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent heart failure | — | AUROC: 0.616 | R²: 0.03455 | age, sex, four first principal components of genetic ancestry | — |
| PPM023008 | PGS005300 (Jorda_HF_MTAG-PGS_2024) |
PSS012090| European Ancestry| 12,677 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent heart failure | — | AUROC: 0.612 | R²: 0.03182 | age, sex, four first principal components of genetic ancestry | — |
| PPM023009 | PGS005301 (Jorda_HF_MTAG-PGS_females_2024) |
PSS012091| European Ancestry| 5,152 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent heart failure | — | AUROC: 0.62709 | R²: 0.03046 | age, sex, four first principal components of genetic ancestry | — |
| PPM023010 | PGS005302 (Jorda_HF_MTAG-PGS_males_2024) |
PSS012092| European Ancestry| 7,525 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent heart failure | — | AUROC: 0.57482 | R²: 0.01618 | age, sex, four first principal components of genetic ancestry | — |
| PPM023011 | PGS005303 (Jorda_HF_SingleTrait-PGS-inf_2024) |
PSS012090| European Ancestry| 12,677 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent heart failure | — | AUROC: 0.613 | R²: 0.03272 | age, sex, four first principal components of genetic ancestry | — |
| PPM023012 | PGS005304 (Jorda_HF_SingleTrait-PGS_2024) |
PSS012090| European Ancestry| 12,677 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent heart failure | — | AUROC: 0.611 | R²: 0.03107 | age, sex, four first principal components of genetic ancestry | — |
| PPM023013 | PGS005305 (Jorda_HF_SingleTrait-PGS_females_2024) |
PSS012091| European Ancestry| 5,152 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent heart failure | — | AUROC: 0.628 | R²: 0.03192 | age, sex, four first principal components of genetic ancestry | — |
| PPM023014 | PGS005306 (Jorda_HF_SingleTrait-PGS_males_2024) |
PSS012092| European Ancestry| 7,525 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent heart failure | — | AUROC: 0.57178 | R²: 0.01529 | age, sex, four first principal components of genetic ancestry | — |
| PPM022995 | PGS005287 (Jorda_AF_MTAG-PGS_2024) |
PSS012090| European Ancestry| 12,677 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent atrial fibrillation or flutter | — | AUROC: 0.703 | R²: 0.14693 | age, sex, four first principal components of genetic ancestry | — |
| PPM023001 | PGS005293 (Jorda_CAD_MTAG-PGS_2024) |
PSS012090| European Ancestry| 12,677 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent coronary artery disease defined as myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, unstable angina and chronic ischemic heart disease. | — | AUROC: 0.772 | R²: 0.27974 | age, sex, four first principal components of genetic ancestry | — |
| PPM023002 | PGS005294 (Jorda_CAD_MTAG-PGS_females_2024) |
PSS012091| European Ancestry| 5,152 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent coronary artery disease defined as myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, unstable angina and chronic ischemic heart disease. | — | AUROC: 0.7 | R²: 0.12154 | age, sex, four first principal components of genetic ancestry | — |
| PPM023006 | PGS005298 (Jorda_CAD_SingleTrait-PGS_males_2024) |
PSS012092| European Ancestry| 7,525 individuals |
PGP000759 | Jordà P et al. NPJ Genom Med (2025) |
Reported Trait: Prevalent coronary artery disease defined as myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, unstable angina and chronic ischemic heart disease. | — | AUROC: 0.69191 | R²: 0.15574 | age, sex, four first principal components of genetic ancestry | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS012090 | Atrial fibrillation or flutter | — | 12,677 individuals | — | European | — | MHI | — |
| PSS012091 | Atrial fibrillation or flutter | — | 5,152 individuals, 0.0 % Male samples |
— | European | — | MHI | — |
| PSS012092 | Atrial fibrillation or flutter | — | 7,525 individuals | — | European | — | MHI | — |