Polygenic Score (PGS) ID: PGS005308

Predicted Trait
Reported Trait Psoriasis
Mapped Trait(s) psoriasis (EFO_0000676)
Additional Trait Information Score was developed using GWAS of psoriasis susceptibility and tested on prediction of severe psoriasis (vs. non-severe disease)
Released in PGS Catalog: Jan. 19, 2026
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Score Details

Score Construction
PGS Name GWS-noHLA
Development Method
Name Clumping and thresholding
Parameters GWAS filtered for variants with P<5E-8, top variant taken for each independent LD block of the genome (defined in Berisa et al. 2016, PMID:26395773).
Variants
Original Genome Build hg19
Number of Variants 64
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000760
Citation (link to publication) Saklatvala JR et al. Genome Med (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
52,950 individuals (100%)
PGS Evaluation
European: 100%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 19,842 cases
  • , 33,108 controls
]
 European CASP, Genizon, KIEL, UCSF, WTCCC

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023016 PSS012098|
European Ancestry|
9,426 individuals
 PGP000760 |
Saklatvala JR et al. Genome Med (2025)
 Reported Trait: Severe psoriasis OR: 1.22 [1.15, 1.3] — — — —
PPM023020 PSS012094|
European Ancestry|
14,167 individuals
 PGP000760 |
Saklatvala JR et al. Genome Med (2025)
 Reported Trait: Severe psoriasis OR: 1.25 [1.18, 1.31] — — — —
PPM023024 PSS012096|
European Ancestry|
8,603 individuals
 PGP000760 |
Saklatvala JR et al. Genome Med (2025)
 Reported Trait: Severe psoriasis OR: 1.23 [1.17, 1.31] — — — —
PPM023028 PSS012095|
European Ancestry|
12,708 individuals
 PGP000760 |
Saklatvala JR et al. Genome Med (2025)
 Reported Trait: Severe psoriasis OR: 1.19 [1.15, 1.24] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012094 — —
[
  • 1,639 cases
  • , 12,528 controls
]
 — European
(Estonian)		 — EB —
PSS012095 — —
[
  • 5,365 cases
  • , 7,343 controls
]
 — European
(Finnish)		 — FinnGen —
PSS012096 — —
[
  • 1,491 cases
  • , 7,112 controls
]
 — European
(Norwegian)		 — HUNT —
PSS012098 — —
[
  • 1,243 cases
  • , 8,183 controls
]
 — European
(British)		 — UKB —