PGS Catalog - Saklatvala JR, Genome Med (2025) (Publication)

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score ID & Name	PGS Publication ID (PGP)	Reported Trait	Mapped Trait(s) (Ontology)	Number of Variants	Ancestry distribution GWAS Dev Eval	Scoring File (FTP Link)
PGS005308 (GWS-noHLA)	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Psoriasis	psoriasis	64	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005308/ScoringFiles/PGS005308.txt.gz
PGS005310 (Full-noHLA)	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Psoriasis	psoriasis	513,460	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005310/ScoringFiles/PGS005310.txt.gz
PGS005307 (GWS)	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Psoriasis	psoriasis	64	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005307/ScoringFiles/PGS005307.txt.gz
PGS005311 (Full_subset)	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Psoriasis	psoriasis	487,311	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005311/ScoringFiles/PGS005311.txt.gz
PGS005312 (Full-noHLA_subset)	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Psoriasis	psoriasis	487,310	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005312/ScoringFiles/PGS005312.txt.gz
PGS005309 (Full)	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Psoriasis	psoriasis	513,461	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005309/ScoringFiles/PGS005309.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM)	Evaluated Score	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM023015	PGS005307 (GWS)	PSS012098\| European Ancestry\| 9,426 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.19 [1.12, 1.26]	—	—	—	—
PPM023016	PGS005308 (GWS-noHLA)	PSS012098\| European Ancestry\| 9,426 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.22 [1.15, 1.3]	—	—	—	—
PPM023017	PGS005309 (Full)	PSS012098\| European Ancestry\| 9,426 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.33 [1.25, 1.41]	—	—	—	—
PPM023018	PGS005310 (Full-noHLA)	PSS012098\| European Ancestry\| 9,426 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.4 [1.32, 1.49]	—	—	—	—
PPM023019	PGS005307 (GWS)	PSS012094\| European Ancestry\| 14,167 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.44 [1.36, 1.51]	—	—	—	—
PPM023020	PGS005308 (GWS-noHLA)	PSS012094\| European Ancestry\| 14,167 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.25 [1.18, 1.31]	—	—	—	—
PPM023021	PGS005309 (Full)	PSS012094\| European Ancestry\| 14,167 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.49 [1.41, 1.57]	—	—	—	—
PPM023022	PGS005310 (Full-noHLA)	PSS012094\| European Ancestry\| 14,167 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.38 [1.31, 1.45]	—	—	—	—
PPM023023	PGS005307 (GWS)	PSS012096\| European Ancestry\| 8,603 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.26 [1.19, 1.33]	—	—	—	—
PPM023024	PGS005308 (GWS-noHLA)	PSS012096\| European Ancestry\| 8,603 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.23 [1.17, 1.31]	—	—	—	—
PPM023025	PGS005309 (Full)	PSS012096\| European Ancestry\| 8,603 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.29 [1.22, 1.36]	—	—	—	—
PPM023026	PGS005310 (Full-noHLA)	PSS012096\| European Ancestry\| 8,603 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.25 [1.19, 1.33]	—	—	—	—
PPM023027	PGS005307 (GWS)	PSS012095\| European Ancestry\| 12,708 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.22 [1.17, 1.26]	—	—	—	—
PPM023028	PGS005308 (GWS-noHLA)	PSS012095\| European Ancestry\| 12,708 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.19 [1.15, 1.24]	—	—	—	—
PPM023029	PGS005309 (Full)	PSS012095\| European Ancestry\| 12,708 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.23 [1.18, 1.27]	—	—	—	—
PPM023030	PGS005310 (Full-noHLA)	PSS012095\| European Ancestry\| 12,708 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis	OR: 1.23 [1.18, 1.28]	—	—	—	—
PPM023031	PGS005311 (Full_subset)	PSS012093\| European Ancestry\| 13,577 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis (BSTOP) vs. any psoriasis (UKB)	—	—	Percentage of cases with risk >95th percentile of UKB psoraisis cases: 15.3	—	—
PPM023032	PGS005312 (Full-noHLA_subset)	PSS012093\| European Ancestry\| 13,577 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis (BSTOP) vs. any psoriasis (UKB)	—	—	Percentage of cases with risk >95th percentile of UKB psoraisis cases: 15.3	—	—
PPM023033	PGS005311 (Full_subset)	PSS012097\| European Ancestry\| 10,887 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis (Novartis) vs. any psoriasis (UKB)	—	—	Percentage of cases with risk >95th percentile of UKB psoraisis cases: 11.6	—	—
PPM023034	PGS005312 (Full-noHLA_subset)	PSS012097\| European Ancestry\| 10,887 individuals	PGP000760 \| Saklatvala JR et al. Genome Med (2025)	Reported Trait: Severe psoriasis (Novartis) vs. any psoriasis (UKB)	—	—	Percentage of cases with risk >95th percentile of UKB psoraisis cases: 11.5	—	—

Evaluated Samples

PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS012093	—	—	4,151 individuals	—	European	—	BSTOP	4,151 in BSTOP is compared against 9426 UKB
PSS012093	—	—	9,426 individuals	—	European	—	UKB	4,151 in BSTOP is compared against 9426 UKB
PSS012094	—	—	14,167 individuals [ 1,639 cases , 12,528 controls ]	—	European (Estonian)	—	EB	—
PSS012095	—	—	12,708 individuals [ 5,365 cases , 7,343 controls ]	—	European (Finnish)	—	FinnGen	—
PSS012096	—	—	8,603 individuals [ 1,491 cases , 7,112 controls ]	—	European (Norwegian)	—	HUNT	—
PSS012097	—	—	1,461 individuals	—	European	—	Novartis	1,461 in Novartis is compared against 9426 UKB
PSS012097	—	—	9,426 individuals	—	European	—	UKB	1,461 in Novartis is compared against 9426 UKB
PSS012098	—	—	9,426 individuals [ 1,243 cases , 8,183 controls ]	—	European (British)	—	UKB	—

Publication Information (EuropePMC)
Title	Genetic liability to psoriasis predicts severe disease outcomes.
PubMed ID	41408349(Europe PMC)
doi	10.1186/s13073-025-01561-2
Publication Date	Dec. 17, 2025
Journal	*Genome Med*
Author(s)	Saklatvala JR, Lessard S, Teder-Laving M, Thomas LF, Ramessur R, Zierer J, Åsvold BO, Barton A, Baudry D, Bowes J, Brumpton B, Bruno S, Chandran V, Chatelain C, de Rinaldis E, Elder JT, Ellinghaus D, Foerster J, Franke A, Gladman DD, Gulliver W, Hüffmeier U, Huilaja L, Hveem K, Khader S, Kingo K, Klinger K, Kolbinger F, Kõks S, Liao W, Nair RP, Nititham J, Rahman P, Reis A, Sagoo MK, Stuart PE, Tasanen K, Traks T, Tsoi LC, Uebe S, Watts K, BSTOP study group, Barker JN, Mahil SK, Langan SM, FinnGen, Estonian Biobank research team, Brown SJ, Løset M, Paternoster L, Dand N, Smith CH, Simpson MA.

PGS Publication: PGP000760

Associated Polygenic Score(s)

PGS Developed By This Publication

Performance Metrics

Evaluated Samples