Polygenic Score (PGS) ID: PGS005313

Predicted Trait
Reported Trait Atrial fibrillation
Mapped Trait(s) atrial fibrillation (EFO_0000275)
Released in PGS Catalog: Oct. 6, 2025
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name AF_PGS_YuanS
Development Method
Name PRS-CSx
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 1,271,239
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000761
Citation (link to publication) Yuan S et al. Nat Commun (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 85.6%
East Asian: 5.8%
African: 4.6%
South Asian: 2%
Hispanic or Latin American: 1.9%
2,584,013 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • African
  • South Asian
  • East Asian
  • Hispanic or Latin American
  • Additional Diverse Ancestries
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90624411
Europe PMC: 40645996
 2,212,177 individuals European 11 cohorts
  • AFGen
  • ,BBJ
  • ,FinnGen
  • ,G&H
  • ,HUNT
  • ,MGI
  • ,MVP
  • ,MyCode
  • ,SIMPLER
  • ,UKB
  • ,deCODE
GWAS Catalog: GCST90624411
Europe PMC: 40645996
 150,272 individuals East Asian 11 cohorts
  • AFGen
  • ,BBJ
  • ,FinnGen
  • ,G&H
  • ,HUNT
  • ,MGI
  • ,MVP
  • ,MyCode
  • ,SIMPLER
  • ,UKB
  • ,deCODE
GWAS Catalog: GCST90624411
Europe PMC: 40645996
 52,808 individuals South Asian 11 cohorts
  • AFGen
  • ,BBJ
  • ,FinnGen
  • ,G&H
  • ,HUNT
  • ,MGI
  • ,MVP
  • ,MyCode
  • ,SIMPLER
  • ,UKB
  • ,deCODE
GWAS Catalog: GCST90624411
Europe PMC: 40645996
 118,491 individuals African unspecified 11 cohorts
  • AFGen
  • ,BBJ
  • ,FinnGen
  • ,G&H
  • ,HUNT
  • ,MGI
  • ,MVP
  • ,MyCode
  • ,SIMPLER
  • ,UKB
  • ,deCODE
GWAS Catalog: GCST90624411
Europe PMC: 40645996
 50,265 individuals Hispanic or Latin American 11 cohorts
  • AFGen
  • ,BBJ
  • ,FinnGen
  • ,G&H
  • ,HUNT
  • ,MGI
  • ,MVP
  • ,MyCode
  • ,SIMPLER
  • ,UKB
  • ,deCODE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023035 PSS012099|
Multi-ancestry (including European)|
37,161 individuals
 PGP000761 |
Yuan S et al. Nat Commun (2025)
 Reported Trait: atrial fibrillation OR: 1.82 [1.79, 1.85] AUROC: 0.78 [0.778, 0.783] — age, sex Tested in Penn Medicine Biobank (4401 individuals with AF and 32,760 individuals without AF)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012099 — —
[
  • 4,401 cases
  • , 32,760 controls
]
 — European, African unspecified, South Asian, East Asian, Hispanic or Latin American, Other — PMB —