PGS Publication: PGP000761

Publication Information (EuropePMC)
Title Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.
PubMed ID 40645996(Europe PMC)
doi 10.1038/s41467-025-61720-2
Publication Date July 11, 2025
Journal Nat Commun
Author(s) Yuan S, Chen J, Ruan X, Li Y, Abramowitz SA, Wang L, Jiang F, Xiong Y, Levin MG, Voight BF, Gill D, Burgess S, Åkesson A, Michaëlsson K, Li X, Damrauer SM, Larsson SC.
Released in PGS Catalog: Oct. 6, 2025

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005313
(AF_PGS_YuanS)
 PGP000761 |
Yuan S et al. Nat Commun (2025)
 Atrial fibrillation atrial fibrillation 1,271,239
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005313/ScoringFiles/PGS005313.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023035 PGS005313
(AF_PGS_YuanS)
 PSS012099|
Multi-ancestry (including European)|
37,161 individuals
 PGP000761 |
Yuan S et al. Nat Commun (2025)
 Reported Trait: atrial fibrillation OR: 1.82 [1.79, 1.85] AUROC: 0.78 [0.778, 0.783] — age, sex Tested in Penn Medicine Biobank (4401 individuals with AF and 32,760 individuals without AF)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012099 — —
[
  • 4,401 cases
  • , 32,760 controls
]
 — European, African unspecified, South Asian, East Asian, Hispanic or Latin American, Other — PMB —