Polygenic Score (PGS) ID: PGS005314

Predicted Trait
Reported Trait Type 2 diabetes (T2D)
Mapped Trait(s) type 2 diabetes mellitus (MONDO_0005148)
Released in PGS Catalog: Oct. 6, 2025
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name T2D_PRS_AA
Development Method
Name PRS-CS
Parameters phi shrinkage parameter = 0.01
Variants
Original Genome Build GRCh37
Number of Variants 1,181,614
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000762
Citation (link to publication) Irvin MR et al. Diabetes (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
African: 100%
96,489 individuals (100%)
PGS Evaluation
African: 100%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 23743551
[
  • 2,688 cases
  • , 9,784 controls
]
 African American or Afro-Caribbean eMERGE
Europe PMC: 15990444
[
  • 1,659 cases
  • , 5,086 controls
]
 African American or Afro-Caribbean REGARDS
GWAS Catalog: GCST002560
Europe PMC: 25102180
 23,827 individuals African American or Afro-Caribbean MEDIA
Europe PMC: 25102180
[
  • 23,305 cases
  • , 30,140 controls
]
 African American or Afro-Caribbean MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023036 PSS012101|
African Ancestry|
1,896 individuals
 PGP000762 |
Irvin MR et al. Diabetes (2024)
 Reported Trait: T2D OR: 1.6 [1.37, 1.88] AUROC: 0.74 — age, sex, and top 10 PC —
PPM023037 PSS012102|
African Ancestry|
655 individuals
 PGP000762 |
Irvin MR et al. Diabetes (2024)
 Reported Trait: T2D OR: 1.4 [1.16, 1.7] AUROC: 0.63 — age, sex, and top 10 PC —
PPM023038 PSS012100|
African Ancestry|
4,724 individuals
 PGP000762 |
Irvin MR et al. Diabetes (2024)
 Reported Trait: T2D OR: 1.45 [1.3, 1.62] AUROC: 0.74 — age, sex, and top 10 PC —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012100 — —
[
  • 1,235 cases
  • , 3,489 controls
]
,
41.02 % Male samples
 Mean = 56.28 years
Sd = 16.02 years		 African American or Afro-Caribbean — BioMe —
PSS012101 — —
[
  • 402 cases
  • , 1,494 controls
]
,
36.48 % Male samples
 Mean = 47.01 years
Sd = 12.81 years		 African American or Afro-Caribbean — HYPERGEN —
PSS012102 — —
[
  • 300 cases
  • , 355 controls
]
,
42.44 % Male samples
 Mean = 57.48 years
Sd = 15.24 years		 African American or Afro-Caribbean — WPC —