PGS Publication: PGP000762

Publication Information (EuropePMC)
Title Polygenic Risk for Type 2 Diabetes in African Americans.
PubMed ID 38470993(Europe PMC)
doi 10.2337/db23-0232
Publication Date June 1, 2024
Journal Diabetes
Author(s) Irvin MR, Ge T, Patki A, Srinivasasainagendra V, Armstrong ND, Davis B, Jones AC, Perez E, Stalbow L, Lebo M, Kenny E, Loos RJF, Ng MCY, Smoller JW, Meigs JB, Lange LA, Karlson EW, Limdi NA, Tiwari HK.
Released in PGS Catalog: Oct. 6, 2025

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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African
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South Asian
Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005314
(T2D_PRS_AA)
 PGP000762 |
Irvin MR et al. Diabetes (2024)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,181,614
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005314/ScoringFiles/PGS005314.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023036 PGS005314
(T2D_PRS_AA)
 PSS012101|
African Ancestry|
1,896 individuals
 PGP000762 |
Irvin MR et al. Diabetes (2024)
 Reported Trait: T2D OR: 1.6 [1.37, 1.88] AUROC: 0.74 — age, sex, and top 10 PC —
PPM023037 PGS005314
(T2D_PRS_AA)
 PSS012102|
African Ancestry|
655 individuals
 PGP000762 |
Irvin MR et al. Diabetes (2024)
 Reported Trait: T2D OR: 1.4 [1.16, 1.7] AUROC: 0.63 — age, sex, and top 10 PC —
PPM023038 PGS005314
(T2D_PRS_AA)
 PSS012100|
African Ancestry|
4,724 individuals
 PGP000762 |
Irvin MR et al. Diabetes (2024)
 Reported Trait: T2D OR: 1.45 [1.3, 1.62] AUROC: 0.74 — age, sex, and top 10 PC —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012100 — —
[
  • 1,235 cases
  • , 3,489 controls
]
,
41.02 % Male samples
 Mean = 56.28 years
Sd = 16.02 years		 African American or Afro-Caribbean — BioMe —
PSS012101 — —
[
  • 402 cases
  • , 1,494 controls
]
,
36.48 % Male samples
 Mean = 47.01 years
Sd = 12.81 years		 African American or Afro-Caribbean — HYPERGEN —
PSS012102 — —
[
  • 300 cases
  • , 355 controls
]
,
42.44 % Male samples
 Mean = 57.48 years
Sd = 15.24 years		 African American or Afro-Caribbean — WPC —