Polygenic Score (PGS) ID: PGS005320

Predicted Trait
Reported Trait Lipoprotein (a)
Mapped Trait(s) lipoprotein A measurement (EFO_0006925)
Released in PGS Catalog: Oct. 6, 2025
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Score Details

Score Construction
PGS Name LPA_PRS
Development Method
Name Genome-wide significant SNPs
Parameters p<5E-08
Variants
Original Genome Build NR
Number of Variants 36
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000766
Citation (link to publication) Türkmen D et al. Pharmacogenomics J (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
20,793 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 29926099
 20,793 individuals European CCHS, CGPS, EPIC, PROSPER, WOSCOPS

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023061 PSS012106|
European Ancestry|
32,360 individuals
 PGP000766 |
Türkmen D et al. Pharmacogenomics J (2024)
 Reported Trait: Incident heart failure HR: 1.09 [1.04, 1.14] — — sex, age at first prescription and genetic principal components 1 to 10 —
PPM023062 PSS012106|
European Ancestry|
32,360 individuals
 PGP000766 |
Türkmen D et al. Pharmacogenomics J (2024)
 Reported Trait: Coronary heart disease HR: 1.11 [1.08, 1.14] — — sex, age at first prescription and genetic principal components 1 to 10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012106 — — 32,360 individuals,
54.4 % Male samples
 — European — UKB —