PGS Catalog - Türkmen D, Pharmacogenomics J (2024) (Publication)

PGS Publication: PGP000766

Publication Information (EuropePMC)
Title	Polygenic scores for cardiovascular risk factors improve estimation of clinical outcomes in CCB treatment compared to pharmacogenetic variants alone.
PubMed ID	38632276(Europe PMC)
doi	10.1038/s41397-024-00333-2
Publication Date	April 17, 2024
Journal	*Pharmacogenomics J*
Author(s)	Türkmen D, Bowden J, Masoli JAH, Delgado J, Kuo CL, Melzer D, Pilling LC.

Released in PGS Catalog: Oct. 6, 2025

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score ID & Name	PGS Publication ID (PGP)	Reported Trait	Mapped Trait(s) (Ontology)	Number of Variants	Ancestry distribution GWAS Dev Eval	Scoring File (FTP Link)
PGS005315 (ALM_PRS)	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Appendicular lean mass	lean body mass	630	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005315/ScoringFiles/PGS005315.txt.gz
PGS005316 (BFM_PRS)	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Body fat mass	body fat distribution	403	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005316/ScoringFiles/PGS005316.txt.gz
PGS005317 (DBP_PRS)	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Diastolic blood pressure	diastolic blood pressure	297	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005317/ScoringFiles/PGS005317.txt.gz
PGS005318 (eGFR_PRS)	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	eGFR	glomerular filtration rate	49	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005318/ScoringFiles/PGS005318.txt.gz
PGS005319 (HF_PRS)	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Heart failure	heart failure	12	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005319/ScoringFiles/PGS005319.txt.gz
PGS005320 (LPA_PRS)	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Lipoprotein (a)	lipoprotein A measurement	36	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005320/ScoringFiles/PGS005320.txt.gz
PGS005321 (SBP_PRS)	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Systolic blood pressure	systolic blood pressure	240	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005321/ScoringFiles/PGS005321.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM)	Evaluated Score	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM023056	PGS005316 (BFM_PRS)	PSS012106\| European Ancestry\| 32,360 individuals	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Reported Trait: Incident heart failure	HR: 1.12 [1.07, 1.18]	—	—	sex, age at first prescription and genetic principal components 1 to 10	—
PPM023057	PGS005316 (BFM_PRS)	PSS012106\| European Ancestry\| 32,360 individuals	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Reported Trait: Coronary heart disease	HR: 1.05 [1.02, 1.08]	—	—	sex, age at first prescription and genetic principal components 1 to 10	—
PPM023058	PGS005316 (BFM_PRS)	PSS012106\| European Ancestry\| 32,360 individuals	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Reported Trait: Discontinuation of dCCB prescribing	HR: 1.04 [1.02, 1.06]	—	—	sex, age at first prescription and genetic principal components 1 to 10	—
PPM023059	PGS005315 (ALM_PRS)	PSS012106\| European Ancestry\| 32,360 individuals	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Reported Trait: Incident heart failure	HR: 1.06 [1.01, 1.11]	—	—	sex, age at first prescription and genetic principal components 1 to 10	—
PPM023060	PGS005315 (ALM_PRS)	PSS012106\| European Ancestry\| 32,360 individuals	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Reported Trait: Discontinuation of dCCB prescribing	HR: 1.02 [1.0, 1.04]	—	—	sex, age at first prescription and genetic principal components 1 to 10	—
PPM023061	PGS005320 (LPA_PRS)	PSS012106\| European Ancestry\| 32,360 individuals	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Reported Trait: Incident heart failure	HR: 1.09 [1.04, 1.14]	—	—	sex, age at first prescription and genetic principal components 1 to 10	—
PPM023062	PGS005320 (LPA_PRS)	PSS012106\| European Ancestry\| 32,360 individuals	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Reported Trait: Coronary heart disease	HR: 1.11 [1.08, 1.14]	—	—	sex, age at first prescription and genetic principal components 1 to 10	—
PPM023063	PGS005321 (SBP_PRS)	PSS012106\| European Ancestry\| 32,360 individuals	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Reported Trait: Discontinuation of dCCB prescribing	HR: 0.96 [0.94, 0.98]	—	—	sex, age at first prescription and genetic principal components 1 to 10	—
PPM023064	PGS005317 (DBP_PRS)	PSS012106\| European Ancestry\| 32,360 individuals	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Reported Trait: Discontinuation of dCCB prescribing	HR: 0.98 [0.96, 1.0]	—	—	sex, age at first prescription and genetic principal components 1 to 10	—
PPM023065	PGS005318 (eGFR_PRS)	PSS012106\| European Ancestry\| 32,360 individuals	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Reported Trait: Chronic kidney disease	HR: 1.06 [1.01, 1.1]	—	—	sex, age at first prescription and genetic principal components 1 to 10	—
PPM023066	PGS005319 (HF_PRS)	PSS012106\| European Ancestry\| 32,360 individuals	PGP000766 \| Türkmen D et al. Pharmacogenomics J (2024)	Reported Trait: Incident heart failure	HR: 1.14 [1.09, 1.19]	—	—	sex, age at first prescription and genetic principal components 1 to 10	—

Evaluated Samples

PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS012106	—	—	32,360 individuals, 54.4 % Male samples	—	European	—	UKB	—