Polygenic Score (PGS) ID: PGS005322

Predicted Trait
Reported Trait Coronary artery disease (Endothelial cell-related)
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: Oct. 6, 2025
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Score Details

Score Construction
PGS Name PRS_EC
Development Method
Name Genome wide significant variants related to Endothelial cell function
Parameters r2>=0.9
Variants
Original Genome Build NR
Number of Variants 36
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000768
Citation (link to publication) Marston NA et al. Nat Med (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 100%
  • European
  • Not Reported
1,165,690 individuals (100%)
PGS Evaluation
European: 100%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90132314
Europe PMC: 36474045
 1,165,690 individuals European, NR 8 cohorts
  • CARDIoGRAMplusC4D
  • ,EPIC_CAD
  • ,GerMIFS
  • ,HUNT
  • ,MGBB
  • ,Other
  • ,UKB
  • ,deCODE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023069 PSS012110|
European Ancestry|
348,967 individuals
 PGP000768 |
Marston NA et al. Nat Med (2025)
 Reported Trait: Incident CAD HR: 1.23 [1.21, 1.26] — — age, sex, population structure (by principal components 1-5), smoking, LDL-C, systolic blood pressure, HbA1c and hsCRP —
PPM023070 PSS012110|
European Ancestry|
348,967 individuals
 PGP000768 |
Marston NA et al. Nat Med (2025)
 Reported Trait: Incident CAD x LDL-C (150 mg/dl) interaction HR: 1.26 [1.22, 1.3] — — — —
PPM023071 PSS012109|
European Ancestry|
8,749 individuals
 PGP000768 |
Marston NA et al. Nat Med (2025)
 Reported Trait: Incident CAD in placebo arm HR: 1.3 [1.1, 1.53] — — — —
PPM023072 PSS012109|
European Ancestry|
8,749 individuals
 PGP000768 |
Marston NA et al. Nat Med (2025)
 Reported Trait: myocardial infarction or coronary revascularization in placebo arm — — Hazard ratio (HR, high vs low tertile): 2.51 [1.27, 4.93] — —
PPM023073 PSS012108|
European Ancestry|
14,298 individuals
 PGP000768 |
Marston NA et al. Nat Med (2025)
 Reported Trait: major vascular events in placebo arm HR: 1.16 [1.08, 1.25] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012108 — — 14,298 individuals,
76.3 % Male samples
 Mean = 62.85 years
Sd = 8.82 years		 European — FOURIER —
PSS012109 — — 8,749 individuals,
67.8 % Male samples
 Mean = 66.1 years
Sd = 7.77 years		 European — JUPITER —
PSS012110 — — 348,967 individuals,
42.4 % Male samples
 Mean = 56.36 years
Sd = 8.05 years		 European — UKB —