PGS Publication: PGP000768

Publication Information (EuropePMC)
Title Endothelial cell-related genetic variants identify LDL cholesterol-sensitive individuals who derive greater benefit from aggressive lipid lowering.
PubMed ID 40011692(Europe PMC)
doi 10.1038/s41591-025-03533-w
Publication Date Feb. 26, 2025
Journal Nat Med
Author(s) Marston NA, Kamanu FK, Melloni GEM, Schnitzler G, Hakim A, Ma RX, Kang H, Chasman DI, Giugliano RP, Ellinor PT, Ridker PM, Engreitz JM, Sabatine MS, Ruff CT, Gupta RM.
Released in PGS Catalog: Oct. 6, 2025

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005322
(PRS_EC)
 PGP000768 |
Marston NA et al. Nat Med (2025)
 Coronary artery disease (Endothelial cell-related) coronary artery disease 36
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005322/ScoringFiles/PGS005322.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023069 PGS005322
(PRS_EC)
 PSS012110|
European Ancestry|
348,967 individuals
 PGP000768 |
Marston NA et al. Nat Med (2025)
 Reported Trait: Incident CAD HR: 1.23 [1.21, 1.26] — — age, sex, population structure (by principal components 1-5), smoking, LDL-C, systolic blood pressure, HbA1c and hsCRP —
PPM023070 PGS005322
(PRS_EC)
 PSS012110|
European Ancestry|
348,967 individuals
 PGP000768 |
Marston NA et al. Nat Med (2025)
 Reported Trait: Incident CAD x LDL-C (150 mg/dl) interaction HR: 1.26 [1.22, 1.3] — — — —
PPM023071 PGS005322
(PRS_EC)
 PSS012109|
European Ancestry|
8,749 individuals
 PGP000768 |
Marston NA et al. Nat Med (2025)
 Reported Trait: Incident CAD in placebo arm HR: 1.3 [1.1, 1.53] — — — —
PPM023072 PGS005322
(PRS_EC)
 PSS012109|
European Ancestry|
8,749 individuals
 PGP000768 |
Marston NA et al. Nat Med (2025)
 Reported Trait: myocardial infarction or coronary revascularization in placebo arm — — Hazard ratio (HR, high vs low tertile): 2.51 [1.27, 4.93] — —
PPM023073 PGS005322
(PRS_EC)
 PSS012108|
European Ancestry|
14,298 individuals
 PGP000768 |
Marston NA et al. Nat Med (2025)
 Reported Trait: major vascular events in placebo arm HR: 1.16 [1.08, 1.25] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012108 — — 14,298 individuals,
76.3 % Male samples
 Mean = 62.85 years
Sd = 8.82 years		 European — FOURIER —
PSS012109 — — 8,749 individuals,
67.8 % Male samples
 Mean = 66.1 years
Sd = 7.77 years		 European — JUPITER —
PSS012110 — — 348,967 individuals,
42.4 % Male samples
 Mean = 56.36 years
Sd = 8.05 years		 European — UKB —