Polygenic Score (PGS) ID: PGS005323

Predicted Trait
Reported Trait Idiopathic pulmonary fibrosis
Mapped Trait(s) idiopathic pulmonary fibrosis (EFO_0000768)
Released in PGS Catalog: Feb. 26, 2026
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Score Details

Score Construction
PGS Name PRS_CS_IPF
Development Method
Name PRS-CS
Parameters effective sample size and global shrinkage parameter phi = 1e-4
Variants
Original Genome Build GRCh37
Number of Variants 653,482
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000769
Citation (link to publication) Zhu J et al. Am J Respir Crit Care Med (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
32,618 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 5,159 cases
  • , 27,459 controls
]
 European
(European)		 NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023074 PSS012111|
European Ancestry|
45,019 individuals
 PGP000769 |
Zhu J et al. Am J Respir Crit Care Med (2025)
 Reported Trait: incident idiopathic pulmonary fibrosis cases HR: 1.61 AUROC: 0.77 — age, age^2, sex, age × sex, age^2 × sex, UKB center, array, and the first 20 principal components of genetic ancestry. —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012111 ICD-10 code J84.1 with exclusion of secondary or other causes of pulmonary fibrosis Median = 10.85 years
[
  • 237 cases
  • , 44,782 controls
]
 — European
(White)		 — UKB —