PGS Publication: PGP000769

Publication Information (EuropePMC)
Title Plasma Proteomic Biomarkers Underlying Polygenic Risk of Idiopathic Pulmonary Fibrosis.
PubMed ID 41151026(Europe PMC)
doi 10.1164/rccm.202505-1202rl
Publication Date Oct. 28, 2025
Journal Am J Respir Crit Care Med
Author(s) Zhu J, Zhou D, Chen Y, You Z, Li Y.
Released in PGS Catalog: Feb. 26, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005323
(PRS_CS_IPF)
 PGP000769 |
Zhu J et al. Am J Respir Crit Care Med (2025)
 Idiopathic pulmonary fibrosis idiopathic pulmonary fibrosis 653,482
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005323/ScoringFiles/PGS005323.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023074 PGS005323
(PRS_CS_IPF)
 PSS012111|
European Ancestry|
45,019 individuals
 PGP000769 |
Zhu J et al. Am J Respir Crit Care Med (2025)
 Reported Trait: incident idiopathic pulmonary fibrosis cases HR: 1.61 AUROC: 0.77 — age, age^2, sex, age × sex, age^2 × sex, UKB center, array, and the first 20 principal components of genetic ancestry. —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012111 ICD-10 code J84.1 with exclusion of secondary or other causes of pulmonary fibrosis Median = 10.85 years
[
  • 237 cases
  • , 44,782 controls
]
 — European
(White)		 — UKB —