Polygenic Score (PGS) ID: PGS005392

Predicted Trait
Reported Trait HOMA2-IR
Mapped Trait(s) HOMA-IR (EFO_0004501)
Additional Trait Information Homeostatsis Model Assessment 2 (HOMA2) - Insulin Resistance
Released in PGS Catalog: Jan. 19, 2026
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Score Details

Score Construction
PGS Name Q-PGS4_r0.2_p5e4
Development Method
Name P + T
Parameters LD (r2) < 0.2, P-value < 5 x 10-4
Variants
Original Genome Build GRCh38
Number of Variants 1,414
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000777
Citation (link to publication) Aliyu U et al. Front Endocrinol (Lausanne) (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Greater Middle Eastern: 100%
2,170 individuals (100%)
PGS Evaluation
Greater Middle Eastern: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90428889
Europe PMC: 38938516
 2,170 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) QBB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023434 PSS012180|
Greater Middle Eastern Ancestry|
4,047 individuals
 PGP000777 |
Aliyu U et al. Front Endocrinol (Lausanne) (2024)
 Reported Trait: HOMA2-IR — — R²: 0.233 gender, age, BMI and PC1 to PC10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012180 — — 4,047 individuals,
42.5 % Male samples
 Mean = 37.8 years
Sd = 12.1 years		 Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)		 — QBB —