PGS Publication: PGP000777

Publication Information (EuropePMC)
Title Genome-wide association study and polygenic score assessment of insulin resistance.
PubMed ID 38938516(Europe PMC)
doi 10.3389/fendo.2024.1384103
Publication Date June 13, 2024
Journal Front Endocrinol (Lausanne)
Author(s) Aliyu U, Umlai UI, Toor SM, Elashi AA, Al-Sarraj YA, Abou Samra AB, Suhre K, Albagha OME.
Released in PGS Catalog: Jan. 19, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005392
(Q-PGS4_r0.2_p5e4)
 PGP000777 |
Aliyu U et al. Front Endocrinol (Lausanne) (2024)
 HOMA2-IR HOMA-IR 1,414
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005392/ScoringFiles/PGS005392.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023434 PGS005392
(Q-PGS4_r0.2_p5e4)
 PSS012180|
Greater Middle Eastern Ancestry|
4,047 individuals
 PGP000777 |
Aliyu U et al. Front Endocrinol (Lausanne) (2024)
 Reported Trait: HOMA2-IR — — R²: 0.233 gender, age, BMI and PC1 to PC10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012180 — — 4,047 individuals,
42.5 % Male samples
 Mean = 37.8 years
Sd = 12.1 years		 Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)		 — QBB —