Polygenic Score (PGS) ID: PGS005397

Predicted Trait
Reported Trait Lung cancer
Mapped Trait(s) lung cancer (MONDO_0008903)
Released in PGS Catalog: May 7, 2026
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Score Details

Score Construction
PGS Name Genome_wide_PRS
Development Method
Name LDpred2-auto
Parameters LD/SNP r2>0.5, P value cut-off was set to 5E-8.
Variants
Original Genome Build GRCh37
Number of Variants 1,022,277
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000780
Citation (link to publication) Boumtje V et al. Transl Oncol (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
85,716 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004748
Europe PMC: 28604730
 85,716 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023440 PSS012185|
European Ancestry|
669 individuals
 PGP000780 |
Boumtje V et al. Transl Oncol (2026)
 Reported Trait: Incident Lung cancer HR: 1.22 C-index: 0.637 — Sex, age,BMI, and the first 10 ancestry-based PCA —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012185 Incident lung cancer was defined by pathological confirmation or radiologic diagnosis. Median = 2.8 years 669 individuals,
47.8 % Male samples
 Mean = 65.4 years European
(French cancadian)		 — QLCSP Quebec Lung Cancer Screening Program