PGS Publication: PGP000780

Publication Information (EuropePMC)
Title Clinical usefulness of polygenic risk scores in risk prediction models for lung cancer screening and lung nodule management.
PubMed ID 41990546(Europe PMC)
doi 10.1016/j.tranon.2026.102771
Publication Date April 15, 2026
Journal Transl Oncol
Author(s) Boumtje V, Li Z, Gaudreault N, Saavedra Armero V, Boudreau DK, Plante S, Biardel S, Eslami A, Martel S, Thériault S, Joubert P, Bossé Y.
Released in PGS Catalog: May 7, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005397
(Genome_wide_PRS)
 PGP000780 |
Boumtje V et al. Transl Oncol (2026)
 Lung cancer lung cancer 1,022,277
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005397/ScoringFiles/PGS005397.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023440 PGS005397
(Genome_wide_PRS)
 PSS012185|
European Ancestry|
669 individuals
 PGP000780 |
Boumtje V et al. Transl Oncol (2026)
 Reported Trait: Incident Lung cancer HR: 1.22 C-index: 0.637 — Sex, age,BMI, and the first 10 ancestry-based PCA —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012185 Incident lung cancer was defined by pathological confirmation or radiologic diagnosis. Median = 2.8 years 669 individuals,
47.8 % Male samples
 Mean = 65.4 years European
(French cancadian)		 — QLCSP Quebec Lung Cancer Screening Program