Polygenic Score (PGS) ID: PGS012522

Predicted Trait
Reported Trait Systolic blood pressure
Mapped Trait(s) systolic blood pressure (EFO_0006335)
Additional Trait Information Continuous cardiovascular trait representing systolic blood pressure (SBP). Summary statistics were obtained from a multi-ethnic genome-wide association study conducted in the Million Veteran Program (PMID: 30578418).
Released in PGS Catalog: June 17, 2026
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Score Details

Score Construction
PGS Name SBP_LD
Development Method
Name LDpred
Parameters Polygenic score constructed using clumping and thresholding (LDpred) with genome-wide significant variants derived from MVP GWAS summary statistics
Variants
Original Genome Build GRCh38
Number of Variants 574,384
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000786
Citation (link to publication) Huang YJ et al. Nat Commun (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 79.6%
African: 13.8%
Hispanic or Latin American: 5%
Additional Asian Ancestries: 1%
Additional Diverse Ancestries: 0.6%
459,777 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • African
  • Hispanic or Latin American
  • Additional Asian Ancestries
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007267
Europe PMC: 30578418
 365,998 individuals European NR
GWAS Catalog: GCST007267
Europe PMC: 30578418
 63,490 individuals African unspecified NR
GWAS Catalog: GCST007267
Europe PMC: 30578418
 22,802 individuals Hispanic or Latin American NR
GWAS Catalog: GCST007267
Europe PMC: 30578418
 4,792 individuals Asian unspecified NR
GWAS Catalog: GCST007267
Europe PMC: 30578418
 2,695 individuals Native American NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030608 PSS012200|
Multi-ancestry (including European)|
49,384 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Systolic blood pressure β: 5.261 (0.154) — — sex, age, age^2, BMI, 11 genetic PCs Effect estimate corresponds to PRS per SD adjusted for genetic PCs.
PPM030609 PSS012200|
Multi-ancestry (including European)|
49,384 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Systolic blood pressure β: 5.209 (0.154) — — sex, age, age^2, BMI, global ancestry proportions Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions.
PPM030610 PSS012200|
Multi-ancestry (including European)|
49,384 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Systolic blood pressure β: 5.213 (0.154) — — sex, age, age^2, BMI, global ePRS Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS).

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012200 — — 27,787 individuals — European — OOA —
PSS012200 — — 11,944 individuals — African American or Afro-Caribbean — OOA —
PSS012200 — — 8,866 individuals — Hispanic or Latin American — OOA —
PSS012200 — — 787 individuals — Asian unspecified — OOA —