| Publication Information (EuropePMC) | |
| Title | Admixture-informed polygenic risk reporting using the ePRS framework. |
| PubMed ID | 42062286(Europe PMC) |
| doi | 10.1038/s41467-026-72457-x |
| Publication Date | April 30, 2026 |
| Journal | Nat Commun |
| Author(s) | Huang YJ, Kurniansyah N, Goodman MO, Spitzer BW, Wang J, Stilp A, Laurie C, de Vries PS, Chen H, Min YI, Sims M, Peloso GM, Guo X, Bis JC, Brody JA, Raffield LM, Smith JA, Zhao W, Rotter JI, Rich SS, Redline S, Fornage M, Kaplan R, Franceschini N, Levy D, Morrison AC, Boerwinkle E, Smith NL, Kooperberg C, Psaty BM, Zöllner S, Trans-Omics for Precision Medicine Consortium, Sofer T. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS012514 (SBP) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Systolic blood pressure | systolic blood pressure | 107 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012514/ScoringFiles/PGS012514.txt.gz |
| PGS012515 (DBP) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Diastolic blood pressure | diastolic blood pressure | 98 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012515/ScoringFiles/PGS012515.txt.gz |
| PGS012518 (BMI) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Body mass index (BMI) | body mass index | 1,440 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012518/ScoringFiles/PGS012518.txt.gz |
| PGS012527 (VTE_LD) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Venous thromboembolism | venous thromboembolism | 516,802 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012527/ScoringFiles/PGS012527.txt.gz |
| PGS012517 (LDL) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
LDL cholesterol | low density lipoprotein cholesterol measurement | 245 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012517/ScoringFiles/PGS012517.txt.gz |
| PGS012519 (VTE) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Venous thromboembolism | venous thromboembolism | 46 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012519/ScoringFiles/PGS012519.txt.gz |
| PGS012520 (OSA_bmi_unadj) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Obstructive sleep apnea | obstructive sleep apnea syndrome | 17 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012520/ScoringFiles/PGS012520.txt.gz |
| PGS012522 (SBP_LD) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Systolic blood pressure | systolic blood pressure | 574,384 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012522/ScoringFiles/PGS012522.txt.gz |
| PGS012523 (DBP_LD) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Diastolic blood pressure | diastolic blood pressure | 574,294 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012523/ScoringFiles/PGS012523.txt.gz |
| PGS012528 (OSA_bmi_unadj_LD) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Obstructive sleep apnea | obstructive sleep apnea syndrome | 307,286 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012528/ScoringFiles/PGS012528.txt.gz |
| PGS012524 (HDL_LD) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
HDL cholesterol | high density lipoprotein cholesterol measurement | 524,956 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012524/ScoringFiles/PGS012524.txt.gz |
| PGS012525 (LDL_LD) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
LDL cholesterol | low density lipoprotein cholesterol measurement | 521,113 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012525/ScoringFiles/PGS012525.txt.gz |
| PGS012526 (BMI_LD) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Body mass index (BMI) | body mass index | 434,712 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012526/ScoringFiles/PGS012526.txt.gz |
| PGS012516 (HDL) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
HDL cholesterol | high density lipoprotein cholesterol measurement | 482 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012516/ScoringFiles/PGS012516.txt.gz |
| PGS012521 (OSA_bmi_adj) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Obstructive sleep apnea (adjusted for BMI) | obstructive sleep apnea syndrome | 6 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012521/ScoringFiles/PGS012521.txt.gz |
| PGS012529 (OSA_bmi_adj_LD) |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Obstructive sleep apnea (adjusted for BMI) | obstructive sleep apnea syndrome | 323,621 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012529/ScoringFiles/PGS012529.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM030559 | PGS012518 (BMI) |
PSS012194| Multi-ancestry (including European)| 49,572 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Body mass index | β: 1.16 (0.026) | — | — | sex, age, age^2, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
| PPM030560 | PGS012518 (BMI) |
PSS012194| Multi-ancestry (including European)| 49,572 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Body mass index | β: 1.15 (0.026) | — | — | sex, age, age^2, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030561 | PGS012518 (BMI) |
PSS012194| Multi-ancestry (including European)| 49,572 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Body mass index | β: 1.16 (0.026) | — | — | sex, age, age^2, local ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for local expected PRS (lePRS). |
| PPM030562 | PGS012515 (DBP) |
PSS012195| Multi-ancestry (including European)| 49,376 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Diastolic blood pressure | β: 1.4 (0.061) | — | — | sex, age, age^2, BMI, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030563 | PGS012515 (DBP) |
PSS012195| Multi-ancestry (including European)| 49,376 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Diastolic blood pressure | β: 1.41 (0.061) | — | — | sex, age, age^2, BMI, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
| PPM030564 | PGS012515 (DBP) |
PSS012195| Multi-ancestry (including European)| 49,376 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Diastolic blood pressure | β: 1.4 (0.061) | — | — | sex, age, age^2, BMI, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030565 | PGS012515 (DBP) |
PSS012195| Multi-ancestry (including European)| 49,376 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Diastolic blood pressure | β: 1.52 (0.062) | — | — | sex, age, age^2, BMI, local ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for local expected PRS (lePRS). |
| PPM030566 | PGS012516 (HDL) |
PSS012196| Multi-ancestry (including European)| 42,931 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: High-density lipoprotein cholesterol levels | β: 4.15 (0.066) | — | — | sex, age, age^2, BMI, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030567 | PGS012516 (HDL) |
PSS012196| Multi-ancestry (including European)| 42,931 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: High-density lipoprotein cholesterol levels | β: 4.15 (0.066) | — | — | sex, age, age^2, BMI, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
| PPM030568 | PGS012516 (HDL) |
PSS012196| Multi-ancestry (including European)| 42,931 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: High-density lipoprotein cholesterol levels | β: 4.15 (0.066) | — | — | sex, age, age^2, BMI, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030569 | PGS012516 (HDL) |
PSS012196| Multi-ancestry (including European)| 42,931 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: High-density lipoprotein cholesterol levels | β: 4.21 (0.066) | — | — | sex, age, age^2, BMI, local ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for local expected PRS (lePRS). |
| PPM030570 | PGS012517 (LDL) |
PSS012197| Multi-ancestry (including European)| 38,463 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Low-density lipoprotein cholesterol levels | β: 13.33 (0.279) | — | — | sex, age, age^2, BMI, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030571 | PGS012517 (LDL) |
PSS012197| Multi-ancestry (including European)| 38,463 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Low-density lipoprotein cholesterol levels | β: 13.33 (0.279) | — | — | sex, age, age^2, BMI, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
| PPM030572 | PGS012517 (LDL) |
PSS012197| Multi-ancestry (including European)| 38,463 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Low-density lipoprotein cholesterol levels | β: 13.32 (0.28) | — | — | sex, age, age^2, BMI, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030573 | PGS012517 (LDL) |
PSS012197| Multi-ancestry (including European)| 38,463 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Low-density lipoprotein cholesterol levels | β: 13.21 (0.284) | — | — | sex, age, age^2, BMI, local ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for local expected PRS (lePRS). |
| PPM030574 | PGS012521 (OSA_bmi_adj) |
PSS012199| Multi-ancestry (including European)| 16,422 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Obstructive sleep apnea (adjusted for BMI) | β: 0.07 (0.024) | — | — | sex, age, age^2, BMI, BMI^2, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030575 | PGS012521 (OSA_bmi_adj) |
PSS012199| Multi-ancestry (including European)| 16,422 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Obstructive sleep apnea (adjusted for BMI) | β: 0.069 (0.024) | — | — | sex, age, age^2, BMI, BMI^2, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
| PPM030576 | PGS012521 (OSA_bmi_adj) |
PSS012199| Multi-ancestry (including European)| 16,422 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Obstructive sleep apnea (adjusted for BMI) | β: 0.068 (0.024) | — | — | sex, age, age^2, BMI, BMI^2, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030577 | PGS012521 (OSA_bmi_adj) |
PSS012199| Multi-ancestry (including European)| 16,422 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Obstructive sleep apnea (adjusted for BMI) | β: 0.069 (0.024) | — | — | sex, age, age^2, BMI, BMI^2, local ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for local expected PRS (lePRS). |
| PPM030578 | PGS012520 (OSA_bmi_unadj) |
PSS012199| Multi-ancestry (including European)| 16,422 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Obstructive sleep apnea | β: 0.004 (0.025) | — | — | sex, age, age^2, BMI, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030579 | PGS012520 (OSA_bmi_unadj) |
PSS012199| Multi-ancestry (including European)| 16,422 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Obstructive sleep apnea | β: 0.003 (0.026) | — | — | sex, age, age^2, BMI, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
| PPM030580 | PGS012520 (OSA_bmi_unadj) |
PSS012199| Multi-ancestry (including European)| 16,422 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Obstructive sleep apnea | β: 0.003 (0.026) | — | — | sex, age, age^2, BMI, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030581 | PGS012520 (OSA_bmi_unadj) |
PSS012199| Multi-ancestry (including European)| 16,422 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Obstructive sleep apnea | β: 0.004 (0.026) | — | — | sex, age, age^2, BMI, local ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for local expected PRS (lePRS). |
| PPM030582 | PGS012514 (SBP) |
PSS012200| Multi-ancestry (including European)| 49,384 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Systolic blood pressure | β: 1.99 (0.088) | — | — | sex, age, age^2, BMI, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030583 | PGS012514 (SBP) |
PSS012200| Multi-ancestry (including European)| 49,384 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Systolic blood pressure | β: 1.99 (0.088) | — | — | sex, age, age^2, BMI, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
| PPM030584 | PGS012514 (SBP) |
PSS012200| Multi-ancestry (including European)| 49,384 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Systolic blood pressure | β: 1.99 (0.088) | — | — | sex, age, age^2, BMI, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030585 | PGS012514 (SBP) |
PSS012200| Multi-ancestry (including European)| 49,384 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Systolic blood pressure | β: 2.01 (0.09) | — | — | sex, age, age^2, BMI, local ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for local expected PRS (lePRS). |
| PPM030586 | PGS012519 (VTE) |
PSS012201| Multi-ancestry (including European)| 9,115 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Venous thromboembolism risk | β: 0.36 (0.027) | — | — | sex, age, age^2, BMI, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030587 | PGS012519 (VTE) |
PSS012201| Multi-ancestry (including European)| 9,115 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Venous thromboembolism risk | β: 0.35 (0.026) | — | — | sex, age, age^2, BMI, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
| PPM030588 | PGS012519 (VTE) |
PSS012201| Multi-ancestry (including European)| 9,115 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Venous thromboembolism risk | β: 0.355 (0.026) | — | — | sex, age, age^2, BMI, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030589 | PGS012519 (VTE) |
PSS012201| Multi-ancestry (including European)| 9,115 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Venous thromboembolism risk | β: 0.354 (0.026) | — | — | sex, age, age^2, BMI, local ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for local expected PRS (lePRS). |
| PPM030590 | PGS012526 (BMI_LD) |
PSS012194| Multi-ancestry (including European)| 49,572 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Body mass index | β: 1.538 (0.028) | — | — | sex, age, age^2, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030591 | PGS012526 (BMI_LD) |
PSS012194| Multi-ancestry (including European)| 49,572 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Body mass index | β: 1.546 (0.028) | — | — | sex, age, age^2, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
| PPM030592 | PGS012526 (BMI_LD) |
PSS012194| Multi-ancestry (including European)| 49,572 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Body mass index | β: 1.536 (0.028) | — | — | sex, age, age^2, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030593 | PGS012523 (DBP_LD) |
PSS012195| Multi-ancestry (including European)| 49,376 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Diastolic blood pressure | β: 1.867 (0.063) | — | — | sex, age, age^2, BMI, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030594 | PGS012523 (DBP_LD) |
PSS012195| Multi-ancestry (including European)| 49,376 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Diastolic blood pressure | β: 1.867 (0.063) | — | — | sex, age, age^2, BMI, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
| PPM030595 | PGS012523 (DBP_LD) |
PSS012195| Multi-ancestry (including European)| 49,376 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Diastolic blood pressure | β: 1.867 (0.063) | — | — | sex, age, age^2, BMI, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030596 | PGS012524 (HDL_LD) |
PSS012196| Multi-ancestry (including European)| 42,931 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: High-density lipoprotein cholesterol levels | β: 5.593 (0.138) | — | — | sex, age, age^2, BMI, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030598 | PGS012524 (HDL_LD) |
PSS012196| Multi-ancestry (including European)| 42,931 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: High-density lipoprotein cholesterol levels | β: 5.526 (0.137) | — | — | sex, age, age^2, BMI, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030599 | PGS012525 (LDL_LD) |
PSS012197| Multi-ancestry (including European)| 38,463 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Low-density lipoprotein cholesterol levels | β: 8.074 (0.247) | — | — | sex, age, age^2, BMI, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030600 | PGS012525 (LDL_LD) |
PSS012197| Multi-ancestry (including European)| 38,463 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Low-density lipoprotein cholesterol levels | β: 8.133 (0.247) | — | — | sex, age, age^2, BMI, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
| PPM030601 | PGS012525 (LDL_LD) |
PSS012197| Multi-ancestry (including European)| 38,463 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Low-density lipoprotein cholesterol levels | β: 8.157 (0.248) | — | — | sex, age, age^2, BMI, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030602 | PGS012529 (OSA_bmi_adj_LD) |
PSS012198| Multi-ancestry (including European)| 15,829 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Obstructive sleep apnea (adjusted for BMI) | β: 0.24 (0.05) | — | — | sex, age, age^2, BMI, BMI^2, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030603 | PGS012529 (OSA_bmi_adj_LD) |
PSS012198| Multi-ancestry (including European)| 15,829 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Obstructive sleep apnea (adjusted for BMI) | β: 0.232 (0.05) | — | — | sex, age, age^2, BMI, BMI^2, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
| PPM030604 | PGS012529 (OSA_bmi_adj_LD) |
PSS012198| Multi-ancestry (including European)| 15,829 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Obstructive sleep apnea (adjusted for BMI) | β: 0.225 (0.05) | — | — | sex, age, age^2, BMI, BMI^2, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030605 | PGS012528 (OSA_bmi_unadj_LD) |
PSS012198| Multi-ancestry (including European)| 15,829 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Obstructive sleep apnea | β: 0.174 (0.044) | — | — | sex, age, age^2, BMI, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030606 | PGS012528 (OSA_bmi_unadj_LD) |
PSS012198| Multi-ancestry (including European)| 15,829 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Obstructive sleep apnea | β: 0.166 (0.044) | — | — | sex, age, age^2, BMI, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
| PPM030607 | PGS012528 (OSA_bmi_unadj_LD) |
PSS012198| Multi-ancestry (including European)| 15,829 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Obstructive sleep apnea | β: 0.167 (0.044) | — | — | sex, age, age^2, BMI, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030608 | PGS012522 (SBP_LD) |
PSS012200| Multi-ancestry (including European)| 49,384 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Systolic blood pressure | β: 5.261 (0.154) | — | — | sex, age, age^2, BMI, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030609 | PGS012522 (SBP_LD) |
PSS012200| Multi-ancestry (including European)| 49,384 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Systolic blood pressure | β: 5.209 (0.154) | — | — | sex, age, age^2, BMI, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
| PPM030610 | PGS012522 (SBP_LD) |
PSS012200| Multi-ancestry (including European)| 49,384 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Systolic blood pressure | β: 5.213 (0.154) | — | — | sex, age, age^2, BMI, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030611 | PGS012527 (VTE_LD) |
PSS012201| Multi-ancestry (including European)| 9,115 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Venous thromboembolism risk | β: 0.162 (0.028) | — | — | sex, age, age^2, BMI, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030612 | PGS012527 (VTE_LD) |
PSS012201| Multi-ancestry (including European)| 9,115 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Venous thromboembolism risk | β: 0.163 (0.028) | — | — | sex, age, age^2, BMI, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
| PPM030613 | PGS012527 (VTE_LD) |
PSS012201| Multi-ancestry (including European)| 9,115 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Venous thromboembolism risk | β: 0.161 (0.028) | — | — | sex, age, age^2, BMI, global ePRS | Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS). |
| PPM030558 | PGS012518 (BMI) |
PSS012194| Multi-ancestry (including European)| 49,572 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: Body mass index | β: 1.15 (0.026) | — | — | sex, age, age^2, 11 genetic PCs | Effect estimate corresponds to PRS per SD adjusted for genetic PCs. |
| PPM030597 | PGS012524 (HDL_LD) |
PSS012196| Multi-ancestry (including European)| 42,931 individuals |
PGP000786 | Huang YJ et al. Nat Commun (2026) |
Reported Trait: High-density lipoprotein cholesterol levels | β: 5.522 (0.137) | — | — | sex, age, age^2, BMI, global ancestry proportions | Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions. |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS012194 | — | — | 27,822 individuals | — | European | — | OOA | — |
| PSS012194 | — | — | 11,982 individuals | — | African American or Afro-Caribbean | — | OOA | — |
| PSS012194 | — | — | 8,981 individuals | — | Hispanic or Latin American | — | OOA | — |
| PSS012194 | — | — | 787 individuals | — | Asian unspecified | — | OOA | — |
| PSS012195 | — | — | 27,780 individuals | — | European | — | OOA | — |
| PSS012195 | — | — | 11,943 individuals | — | African American or Afro-Caribbean | — | OOA | — |
| PSS012195 | — | — | 8,866 individuals | — | Hispanic or Latin American | — | OOA | — |
| PSS012195 | — | — | 787 individuals | — | Asian unspecified | — | OOA | — |
| PSS012196 | — | — | 22,909 individuals | — | European | — | OOA | — |
| PSS012196 | — | — | 10,323 individuals | — | African American or Afro-Caribbean | — | OOA | — |
| PSS012196 | — | — | 8,961 individuals | — | Hispanic or Latin American | — | OOA | — |
| PSS012196 | — | — | 738 individuals | — | Asian unspecified | — | OOA | — |
| PSS012197 | — | — | 20,483 individuals | — | European | — | OOA | — |
| PSS012197 | — | — | 8,585 individuals | — | African American or Afro-Caribbean | — | OOA | — |
| PSS012197 | — | — | 8,680 individuals | — | Hispanic or Latin American | — | OOA | — |
| PSS012197 | — | — | 715 individuals | — | Asian unspecified | — | OOA | — |
| PSS012198 | — | — | 5,469 individuals | — | European | — | OOA | — |
| PSS012198 | — | — | 3,029 individuals | — | African American or Afro-Caribbean | — | OOA | — |
| PSS012198 | — | — | 7,103 individuals | — | Hispanic or Latin American | — | OOA | — |
| PSS012198 | — | — | 228 individuals | — | Asian unspecified | — | OOA | — |
| PSS012199 | — | — | 5,835 individuals | — | European | — | OOA | — |
| PSS012199 | — | — | 3,222 individuals | — | African American or Afro-Caribbean | — | OOA | — |
| PSS012199 | — | — | 7,137 individuals | — | Hispanic or Latin American | — | OOA | — |
| PSS012199 | — | — | 228 individuals | — | Asian unspecified | — | OOA | — |
| PSS012200 | — | — | 27,787 individuals | — | European | — | OOA | — |
| PSS012200 | — | — | 11,944 individuals | — | African American or Afro-Caribbean | — | OOA | — |
| PSS012200 | — | — | 8,866 individuals | — | Hispanic or Latin American | — | OOA | — |
| PSS012200 | — | — | 787 individuals | — | Asian unspecified | — | OOA | — |
| PSS012201 | — | — | 7,482 individuals | — | European | — | OOA | — |
| PSS012201 | — | — | 1,520 individuals | — | African American or Afro-Caribbean | — | OOA | — |
| PSS012201 | — | — | 113 individuals | — | Hispanic or Latin American | — | OOA | — |