Polygenic Score (PGS) ID: PGS012526

Predicted Trait
Reported Trait Body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Additional Trait Information Continuous anthropometric trait representing body mass index (BMI), calculated as weight in kilograms divided by height in meters squared (kg/m²)
Released in PGS Catalog: June 17, 2026
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Terms and Licenses
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Score Details

Score Construction
PGS Name BMI_LD
Development Method
Name LDpred
Parameters Polygenic score constructed using clumping and thresholding (LDpred) with genome-wide significant variants derived from MVP GWAS summary statistics
Variants
Original Genome Build GRCh38
Number of Variants 434,712
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000786
Citation (link to publication) Huang YJ et al. Nat Commun (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 67%
Not Reported: 33%
681,275 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • African
  • Hispanic or Latin American
  • Additional Asian Ancestries
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006900
Europe PMC: 30124842
 456,426 individuals European NR
GWAS Catalog: GCST006900
Europe PMC: 30124842
 224,849 individuals NR NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030590 PSS012194|
Multi-ancestry (including European)|
49,572 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Body mass index β: 1.538 (0.028) — — sex, age, age^2, 11 genetic PCs Effect estimate corresponds to PRS per SD adjusted for genetic PCs.
PPM030591 PSS012194|
Multi-ancestry (including European)|
49,572 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Body mass index β: 1.546 (0.028) — — sex, age, age^2, global ancestry proportions Effect estimate corresponds to PRS per SD adjusted for global ancestry proportions.
PPM030592 PSS012194|
Multi-ancestry (including European)|
49,572 individuals
 PGP000786 |
Huang YJ et al. Nat Commun (2026)
 Reported Trait: Body mass index β: 1.536 (0.028) — — sex, age, age^2, global ePRS Effect estimate corresponds to residual PRS (rPRS) adjusted for global expected PRS (gePRS).

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012194 — — 27,822 individuals — European — OOA —
PSS012194 — — 11,982 individuals — African American or Afro-Caribbean — OOA —
PSS012194 — — 8,981 individuals — Hispanic or Latin American — OOA —
PSS012194 — — 787 individuals — Asian unspecified — OOA —