Polygenic Score (PGS) ID: PGS012531

Predicted Trait
Reported Trait Atrial fibrillation
Mapped Trait(s) atrial fibrillation (MONDO_0004981)
Released in PGS Catalog: June 17, 2026
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name ALLmeta
Development Method
Name SBayesRC
Parameters Inputs: GWAS summary statistics, LD reference panel, and annotation file; no additional parameters specified.
Variants
Original Genome Build GRCh38
Number of Variants 7,356,514
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000788
Citation (link to publication) Haydarlou P et al. Nat Commun (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 84.4%
East Asian: 6.8%
African: 5.7%
Hispanic or Latin American: 3%
South Asian: 0.03%
2,272,352 individuals (100%)
PGS Evaluation
East Asian: 28.6%
European: 28.6%
African: 14.3%
Hispanic or Latin American: 14.3%
South Asian: 14.3%
7 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90559230
Europe PMC: 40050429
 11,138 individuals African American or Afro-Caribbean 36 cohorts
  • AFGen
  • ,AGES
  • ,ARIC
  • ,BBJ
  • ,BioMe
  • ,Broad CVDi
  • ,CCAF
  • ,CHB
  • ,CHS
  • ,EGCUT
  • ,ENGAGE_AF-TIMI_48
  • ,FHS
  • ,FinnGen
  • ,GAPP
  • ,GS:SFHS
  • ,HRS
  • ,HUNT
  • ,LURIC
  • ,MESA
  • ,MGI
  • ,MyCode
  • ,Other
  • ,PHB
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,Rotterdam
  • ,SHIP
  • ,SPHFC
  • ,SiGN
  • ,TwinGene
  • ,UKB
  • ,ULSAM
  • ,Vanderbilt
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST90559230
Europe PMC: 40050429
 148,865 individuals East Asian 36 cohorts
  • AFGen
  • ,AGES
  • ,ARIC
  • ,BBJ
  • ,BioMe
  • ,Broad CVDi
  • ,CCAF
  • ,CHB
  • ,CHS
  • ,EGCUT
  • ,ENGAGE_AF-TIMI_48
  • ,FHS
  • ,FinnGen
  • ,GAPP
  • ,GS:SFHS
  • ,HRS
  • ,HUNT
  • ,LURIC
  • ,MESA
  • ,MGI
  • ,MyCode
  • ,Other
  • ,PHB
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,Rotterdam
  • ,SHIP
  • ,SPHFC
  • ,SiGN
  • ,TwinGene
  • ,UKB
  • ,ULSAM
  • ,Vanderbilt
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST90559230
Europe PMC: 40050429
 1,480,272 individuals European 36 cohorts
  • AFGen
  • ,AGES
  • ,ARIC
  • ,BBJ
  • ,BioMe
  • ,Broad CVDi
  • ,CCAF
  • ,CHB
  • ,CHS
  • ,EGCUT
  • ,ENGAGE_AF-TIMI_48
  • ,FHS
  • ,FinnGen
  • ,GAPP
  • ,GS:SFHS
  • ,HRS
  • ,HUNT
  • ,LURIC
  • ,MESA
  • ,MGI
  • ,MyCode
  • ,Other
  • ,PHB
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,Rotterdam
  • ,SHIP
  • ,SPHFC
  • ,SiGN
  • ,TwinGene
  • ,UKB
  • ,ULSAM
  • ,Vanderbilt
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST90559230
Europe PMC: 40050429
 9,439 individuals Hispanic or Latin American 36 cohorts
  • AFGen
  • ,AGES
  • ,ARIC
  • ,BBJ
  • ,BioMe
  • ,Broad CVDi
  • ,CCAF
  • ,CHB
  • ,CHS
  • ,EGCUT
  • ,ENGAGE_AF-TIMI_48
  • ,FHS
  • ,FinnGen
  • ,GAPP
  • ,GS:SFHS
  • ,HRS
  • ,HUNT
  • ,LURIC
  • ,MESA
  • ,MGI
  • ,MyCode
  • ,Other
  • ,PHB
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,Rotterdam
  • ,SHIP
  • ,SPHFC
  • ,SiGN
  • ,TwinGene
  • ,UKB
  • ,ULSAM
  • ,Vanderbilt
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST90559230
Europe PMC: 40050429
 631 individuals South Asian 36 cohorts
  • AFGen
  • ,AGES
  • ,ARIC
  • ,BBJ
  • ,BioMe
  • ,Broad CVDi
  • ,CCAF
  • ,CHB
  • ,CHS
  • ,EGCUT
  • ,ENGAGE_AF-TIMI_48
  • ,FHS
  • ,FinnGen
  • ,GAPP
  • ,GS:SFHS
  • ,HRS
  • ,HUNT
  • ,LURIC
  • ,MESA
  • ,MGI
  • ,MyCode
  • ,Other
  • ,PHB
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,Rotterdam
  • ,SHIP
  • ,SPHFC
  • ,SiGN
  • ,TwinGene
  • ,UKB
  • ,ULSAM
  • ,Vanderbilt
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST90480170
Europe PMC: 39024449
 118,682 individuals African American or Afro-Caribbean MVP
GWAS Catalog: GCST90480170
Europe PMC: 39024449
 58,834 individuals Hispanic or Latin American MVP
GWAS Catalog: GCST90480170
Europe PMC: 39024449
 6,743 individuals East Asian MVP
GWAS Catalog: GCST90480170
Europe PMC: 39024449
 437,748 individuals European MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030617 PSS012204|
European Ancestry|
124,367 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.82
β: 0.597		 — R²: 0.098 age, sex and first 20 principal components Beta = log(OR)
PPM030620 PSS012206|
Hispanic or Latin American Ancestry|
40,219 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.39
β: 0.332		 — R²: 0.032 age, sex and first 20 principal components Beta = log(OR)
PPM030623 PSS012207|
African Ancestry|
44,692 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.32
β: 0.274		 — R²: 0.018 age, sex and first 20 principal components Beta = log(OR)
PPM030626 PSS012208|
South Asian Ancestry|
3,806 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.31
β: 0.27		 — R²: 0.02 age, sex and first 20 principal components Beta = log(OR)
PPM030629 PSS012209|
East Asian Ancestry|
6,832 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.79
β: 0.582		 — R²: 0.075 age, sex and first 20 principal components Beta = log(OR)
PPM030632 PSS012210|
East Asian Ancestry|
45,404 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 2.1
β: 0.744		 — R²: 0.142 age, sex and first 20 principal components Beta = log(OR)
PPM030635 PSS012211|
European Ancestry|
15,191 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 2.19
β: 0.786		 — R²: 0.134 age, sex and first 20 principal components Beta = log(OR)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012204 OMOP.Ids: 313217 and 314665 —
[
  • 11,087 cases
  • , 113,280 controls
]
 — European — AllofUs —
PSS012206 OMOP.Ids: 313217 and 314665 —
[
  • 1,449 cases
  • , 38,770 controls
]
 — Hispanic or Latin American — AllofUs —
PSS012207 OMOP.Ids: 313217 and 314665 —
[
  • 2,112 cases
  • , 42,580 controls
]
 — African American or Afro-Caribbean — AllofUs —
PSS012208 OMOP.Ids: 313217 and 314665 —
[
  • 90 cases
  • , 3,716 controls
]
 — South Asian — AllofUs —
PSS012209 OMOP.Ids: 313217 and 314665 —
[
  • 198 cases
  • , 6,634 controls
]
 — East Asian — AllofUs —
PSS012210 physician's diagnosis or electrocardiogram records —
[
  • 3,944 cases
  • , 41,460 controls
]
 — East Asian
(Japanese)		 — BBJ Biobank Japan 2nd cohort
PSS012211 I48, I48.0, I48.1, I48.2, I48.3, I48.4, I48.9, 427.3. —
[
  • 341 cases
  • , 14,850 controls
]
 — European
(Norwegian)		 — HUNT —