PGS Publication: PGP000788

Publication Information (EuropePMC)
Title Multi-trait polygenic risk scores improve genomic prediction of atrial fibrillation across diverse ancestries.
PubMed ID 42086565(Europe PMC)
doi 10.1038/s41467-026-72708-x
Publication Date May 5, 2026
Journal Nat Commun
Author(s) Haydarlou P, Kramarenko DR, Enzan N, Klevjer M, Vad OB, Corver ME, Zimmerman DS, BioBank Japan Project, Matsuda K, Diederichsen SZ, Bye A, Svendsen JH, Ito K, Ellinor PT, Bezzina CR, Jurgens SJ.
Released in PGS Catalog: June 17, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012533
(Mult-t-AMR)
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Atrial fibrillation atrial fibrillation 7,356,472
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012533/ScoringFiles/PGS012533.txt.gz
PGS012534
(Mult-t-AFR)
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Atrial fibrillation atrial fibrillation 7,356,472
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012534/ScoringFiles/PGS012534.txt.gz
PGS012535
(Mult-t-SAS)
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Atrial fibrillation atrial fibrillation 7,356,472
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012535/ScoringFiles/PGS012535.txt.gz
PGS012536
(Mult-t-EAS)
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Atrial fibrillation atrial fibrillation 7,356,461
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012536/ScoringFiles/PGS012536.txt.gz
PGS012531
(ALLmeta)
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Atrial fibrillation atrial fibrillation 7,356,514
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012531/ScoringFiles/PGS012531.txt.gz
PGS012532
(Mult-t-EUR)
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Atrial fibrillation atrial fibrillation 7,356,472
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012532/ScoringFiles/PGS012532.txt.gz
PGS012537
(UKB_Mult-t-AFR)
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Atrial fibrillation atrial fibrillation 7,356,497
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012537/ScoringFiles/PGS012537.txt.gz
PGS012538
(UKB_Mult-t-SAS)
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Atrial fibrillation atrial fibrillation 7,356,497
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012538/ScoringFiles/PGS012538.txt.gz

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005168
(PRSAF)
 PGP000712 |
Roselli C et al. Nat Genet (2025)
 Atrial fibrillation atrial fibrillation 382,963
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005168/ScoringFiles/PGS005168.txt.gz
PGS004706
(afib_PRSmixPlus_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Atrial Fibrillation atrial fibrillation 3,576,958
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004706/ScoringFiles/PGS004706.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030617 PGS012531
(ALLmeta)
 PSS012204|
European Ancestry|
124,367 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.82
β: 0.597		 — R²: 0.098 age, sex and first 20 principal components Beta = log(OR)
PPM030618 PGS012532
(Mult-t-EUR)
 PSS012204|
European Ancestry|
124,367 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.89
β: 0.635		 — R²: 0.11 age, sex and first 20 principal components Beta = log(OR)
PPM030619 PGS005168
(PRSAF)
 PSS012206|
Hispanic or Latin American Ancestry|
40,219 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
|Ext.		 Reported Trait: Atrial Fibrillation OR: 1.34
β: 0.29		 — R²: 0.024 age, sex and first 20 principal components Beta = log(OR)
PPM030620 PGS012531
(ALLmeta)
 PSS012206|
Hispanic or Latin American Ancestry|
40,219 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.39
β: 0.332		 — R²: 0.032 age, sex and first 20 principal components Beta = log(OR)
PPM030621 PGS012533
(Mult-t-AMR)
 PSS012206|
Hispanic or Latin American Ancestry|
40,219 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.45
β: 0.373		 — R²: 0.043 age, sex and first 20 principal components Beta = log(OR)
PPM030622 PGS005168
(PRSAF)
 PSS012207|
African Ancestry|
44,692 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
|Ext.		 Reported Trait: Atrial Fibrillation OR: 1.21
β: 0.189		 — R²: 0.008 age, sex and first 20 principal components Beta = log(OR)
PPM030623 PGS012531
(ALLmeta)
 PSS012207|
African Ancestry|
44,692 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.32
β: 0.274		 — R²: 0.018 age, sex and first 20 principal components Beta = log(OR)
PPM030624 PGS012534
(Mult-t-AFR)
 PSS012207|
African Ancestry|
44,692 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.39
β: 0.328		 — R²: 0.028 age, sex and first 20 principal components Beta = log(OR)
PPM030625 PGS005168
(PRSAF)
 PSS012208|
South Asian Ancestry|
3,806 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
|Ext.		 Reported Trait: Atrial Fibrillation OR: 1.28
β: 0.247		 — R²: 0.014 age, sex and first 20 principal components Beta = log(OR)
PPM030626 PGS012531
(ALLmeta)
 PSS012208|
South Asian Ancestry|
3,806 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.31
β: 0.27		 — R²: 0.02 age, sex and first 20 principal components Beta = log(OR)
PPM030627 PGS012535
(Mult-t-SAS)
 PSS012208|
South Asian Ancestry|
3,806 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.45
β: 0.369		 — R²: 0.038 age, sex and first 20 principal components Beta = log(OR)
PPM030628 PGS005168
(PRSAF)
 PSS012209|
East Asian Ancestry|
6,832 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
|Ext.		 Reported Trait: Atrial Fibrillation OR: 1.64
β: 0.492		 — R²: 0.061 age, sex and first 20 principal components Beta = log(OR)
PPM030629 PGS012531
(ALLmeta)
 PSS012209|
East Asian Ancestry|
6,832 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.79
β: 0.582		 — R²: 0.075 age, sex and first 20 principal components Beta = log(OR)
PPM030630 PGS012536
(Mult-t-EAS)
 PSS012209|
East Asian Ancestry|
6,832 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.82
β: 0.599		 — R²: 0.079 age, sex and first 20 principal components Beta = log(OR)
PPM030631 PGS005168
(PRSAF)
 PSS012210|
East Asian Ancestry|
45,404 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
|Ext.		 Reported Trait: Atrial Fibrillation OR: 2.0
β: 0.692		 — R²: 0.125 age, sex and first 20 principal components Beta = log(OR)
PPM030632 PGS012531
(ALLmeta)
 PSS012210|
East Asian Ancestry|
45,404 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 2.1
β: 0.744		 — R²: 0.142 age, sex and first 20 principal components Beta = log(OR)
PPM030633 PGS012536
(Mult-t-EAS)
 PSS012210|
East Asian Ancestry|
45,404 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 2.11
β: 0.746		 — R²: 0.143 age, sex and first 20 principal components Beta = log(OR)
PPM030634 PGS005168
(PRSAF)
 PSS012211|
European Ancestry|
15,191 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
|Ext.		 Reported Trait: Atrial Fibrillation OR: 1.81
β: 0.593		 — R²: 0.083 age, sex and first 20 principal components Beta = log(OR)
PPM030635 PGS012531
(ALLmeta)
 PSS012211|
European Ancestry|
15,191 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 2.19
β: 0.786		 — R²: 0.134 age, sex and first 20 principal components Beta = log(OR)
PPM030636 PGS012532
(Mult-t-EUR)
 PSS012211|
European Ancestry|
15,191 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 2.24
β: 0.807		 — R²: 0.143 age, sex and first 20 principal components Beta = log(OR)
PPM030637 PGS004706
(afib_PRSmixPlus_eur)
 PSS012212|
European Ancestry|
5,656 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
|Ext.		 Reported Trait: Atrial Fibrillation OR: 1.38
β: 0.323		 — R²: 0.029 age, sex and first 6 principal components Beta = log(OR)
PPM030638 PGS005168
(PRSAF)
 PSS012212|
European Ancestry|
5,656 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
|Ext.		 Reported Trait: Atrial Fibrillation OR: 1.43
β: 0.356		 — R²: 0.037 age, sex and first 6 principal components Beta = log(OR)
PPM030639 PGS012532
(Mult-t-EUR)
 PSS012212|
European Ancestry|
5,656 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.54
β: 0.429		 — R²: 0.052 age, sex and first 6 principal components Beta = log(OR)
PPM030640 PGS005168
(PRSAF)
 PSS012213|
African Ancestry|
7,382 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
|Ext.		 Reported Trait: Atrial Fibrillation OR: 1.31
β: 0.271		 — R²: 0.015 age, sex and first 20 principal components Beta = log(OR)
PPM030641 PGS012534
(Mult-t-AFR)
 PSS012213|
African Ancestry|
7,382 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.37
β: 0.313		 — R²: 0.019 age, sex and first 20 principal components Beta = log(OR)
PPM030642 PGS005168
(PRSAF)
 PSS012205|
South Asian Ancestry|
4,439 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
|Ext.		 Reported Trait: Atrial Fibrillation OR: 1.44
β: 0.364		 — R²: 0.033 age, sex and first 20 principal components Beta = log(OR)
PPM030643 PGS012535
(Mult-t-SAS)
 PSS012205|
South Asian Ancestry|
4,439 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.75
β: 0.559		 — R²: 0.071 age, sex and first 20 principal components Beta = log(OR)
PPM030616 PGS005168
(PRSAF)
 PSS012204|
European Ancestry|
124,367 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
|Ext.		 Reported Trait: Atrial Fibrillation OR: 1.59
β: 0.463		 — R²: 0.059 age, sex and first 20 principal components Beta = log(OR)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012213 I48, I48.0, I48.1, I48.2, I48.3, I48.4, I48.9, 427.3. —
[
  • 259 cases
  • , 7,123 controls
]
 — African unspecified — UKB —
PSS012204 OMOP.Ids: 313217 and 314665 —
[
  • 11,087 cases
  • , 113,280 controls
]
 — European — AllofUs —
PSS012205 I48, I48.0, I48.1, I48.2, I48.3, I48.4, I48.9, 427.3. —
[
  • 204 cases
  • , 4,235 controls
]
 — South Asian — UKB —
PSS012206 OMOP.Ids: 313217 and 314665 —
[
  • 1,449 cases
  • , 38,770 controls
]
 — Hispanic or Latin American — AllofUs —
PSS012207 OMOP.Ids: 313217 and 314665 —
[
  • 2,112 cases
  • , 42,580 controls
]
 — African American or Afro-Caribbean — AllofUs —
PSS012208 OMOP.Ids: 313217 and 314665 —
[
  • 90 cases
  • , 3,716 controls
]
 — South Asian — AllofUs —
PSS012209 OMOP.Ids: 313217 and 314665 —
[
  • 198 cases
  • , 6,634 controls
]
 — East Asian — AllofUs —
PSS012210 physician's diagnosis or electrocardiogram records —
[
  • 3,944 cases
  • , 41,460 controls
]
 — East Asian
(Japanese)		 — BBJ Biobank Japan 2nd cohort
PSS012211 I48, I48.0, I48.1, I48.2, I48.3, I48.4, I48.9, 427.3. —
[
  • 341 cases
  • , 14,850 controls
]
 — European
(Norwegian)		 — HUNT —
PSS012212 - —
[
  • 969 cases
  • , 4,687 controls
]
 — European
(Danish)		 — LOOP —