Polygenic Score (PGS) ID: PGS012532

Predicted Trait
Reported Trait Atrial fibrillation
Mapped Trait(s) atrial fibrillation (MONDO_0004981)
Released in PGS Catalog: June 17, 2026
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name Mult-t-EUR
Development Method
Name SBayesRC
Parameters Inputs: GWAS summary statistics, LD reference panel, and annotation file; no additional parameters specified.
Variants
Original Genome Build GRCh38
Number of Variants 7,356,472
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000788
Citation (link to publication) Haydarlou P et al. Nat Commun (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 48.1%
Multi-ancestry (including European): 43.5%
  • European
  • Hispanic or Latin American
  • African
  • South Asian
  • East Asian
East Asian: 3.4%
African: 3.3%
Hispanic or Latin American: 1.7%
South Asian: 0.01%
12,191,458 individuals (100%)
Score Development/Training
European: 100%
53,513 individuals (100%)
PGS Evaluation
European: 100%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90559230
Europe PMC: 40050429
 11,138 individuals African American or Afro-Caribbean 36 cohorts
  • AFGen
  • ,AGES
  • ,ARIC
  • ,BBJ
  • ,BioMe
  • ,Broad CVDi
  • ,CCAF
  • ,CHB
  • ,CHS
  • ,EGCUT
  • ,ENGAGE_AF-TIMI_48
  • ,FHS
  • ,FinnGen
  • ,GAPP
  • ,GS:SFHS
  • ,HRS
  • ,HUNT
  • ,LURIC
  • ,MESA
  • ,MGI
  • ,MyCode
  • ,Other
  • ,PHB
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,Rotterdam
  • ,SHIP
  • ,SPHFC
  • ,SiGN
  • ,TwinGene
  • ,UKB
  • ,ULSAM
  • ,Vanderbilt
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST90559230
Europe PMC: 40050429
 148,865 individuals East Asian 36 cohorts
  • AFGen
  • ,AGES
  • ,ARIC
  • ,BBJ
  • ,BioMe
  • ,Broad CVDi
  • ,CCAF
  • ,CHB
  • ,CHS
  • ,EGCUT
  • ,ENGAGE_AF-TIMI_48
  • ,FHS
  • ,FinnGen
  • ,GAPP
  • ,GS:SFHS
  • ,HRS
  • ,HUNT
  • ,LURIC
  • ,MESA
  • ,MGI
  • ,MyCode
  • ,Other
  • ,PHB
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,Rotterdam
  • ,SHIP
  • ,SPHFC
  • ,SiGN
  • ,TwinGene
  • ,UKB
  • ,ULSAM
  • ,Vanderbilt
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST90559230
Europe PMC: 40050429
 1,480,272 individuals European 36 cohorts
  • AFGen
  • ,AGES
  • ,ARIC
  • ,BBJ
  • ,BioMe
  • ,Broad CVDi
  • ,CCAF
  • ,CHB
  • ,CHS
  • ,EGCUT
  • ,ENGAGE_AF-TIMI_48
  • ,FHS
  • ,FinnGen
  • ,GAPP
  • ,GS:SFHS
  • ,HRS
  • ,HUNT
  • ,LURIC
  • ,MESA
  • ,MGI
  • ,MyCode
  • ,Other
  • ,PHB
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,Rotterdam
  • ,SHIP
  • ,SPHFC
  • ,SiGN
  • ,TwinGene
  • ,UKB
  • ,ULSAM
  • ,Vanderbilt
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST90559230
Europe PMC: 40050429
 9,439 individuals Hispanic or Latin American 36 cohorts
  • AFGen
  • ,AGES
  • ,ARIC
  • ,BBJ
  • ,BioMe
  • ,Broad CVDi
  • ,CCAF
  • ,CHB
  • ,CHS
  • ,EGCUT
  • ,ENGAGE_AF-TIMI_48
  • ,FHS
  • ,FinnGen
  • ,GAPP
  • ,GS:SFHS
  • ,HRS
  • ,HUNT
  • ,LURIC
  • ,MESA
  • ,MGI
  • ,MyCode
  • ,Other
  • ,PHB
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,Rotterdam
  • ,SHIP
  • ,SPHFC
  • ,SiGN
  • ,TwinGene
  • ,UKB
  • ,ULSAM
  • ,Vanderbilt
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST90559230
Europe PMC: 40050429
 631 individuals South Asian 36 cohorts
  • AFGen
  • ,AGES
  • ,ARIC
  • ,BBJ
  • ,BioMe
  • ,Broad CVDi
  • ,CCAF
  • ,CHB
  • ,CHS
  • ,EGCUT
  • ,ENGAGE_AF-TIMI_48
  • ,FHS
  • ,FinnGen
  • ,GAPP
  • ,GS:SFHS
  • ,HRS
  • ,HUNT
  • ,LURIC
  • ,MESA
  • ,MGI
  • ,MyCode
  • ,Other
  • ,PHB
  • ,PIVUS
  • ,PREVEND
  • ,PROSPER
  • ,Rotterdam
  • ,SHIP
  • ,SPHFC
  • ,SiGN
  • ,TwinGene
  • ,UKB
  • ,ULSAM
  • ,Vanderbilt
  • ,WGHS
  • ,WTCCC
GWAS Catalog: GCST90480170
Europe PMC: 39024449
 118,682 individuals African American or Afro-Caribbean MVP
GWAS Catalog: GCST90480170
Europe PMC: 39024449
 58,834 individuals Hispanic or Latin American MVP
GWAS Catalog: GCST90480170
Europe PMC: 39024449
 6,743 individuals East Asian MVP
GWAS Catalog: GCST90480170
Europe PMC: 39024449
 437,748 individuals European MVP
GWAS Catalog: GCST90455657
Europe PMC: 40195560
 1,893,921 individuals European 11 cohorts
  • BBJ
  • ,BioMe
  • ,CKB
  • ,FinnGen
  • ,GBMI
  • ,HERMES
  • ,MVP
  • ,MyCode
  • ,PMB
  • ,UCLA
  • ,eMERGE
GWAS Catalog: GCST90455657
Europe PMC: 40195560
 142,872 individuals African unspecified 11 cohorts
  • BBJ
  • ,BioMe
  • ,CKB
  • ,FinnGen
  • ,GBMI
  • ,HERMES
  • ,MVP
  • ,MyCode
  • ,PMB
  • ,UCLA
  • ,eMERGE
GWAS Catalog: GCST90455657
Europe PMC: 40195560
 257,928 individuals East Asian 11 cohorts
  • BBJ
  • ,BioMe
  • ,CKB
  • ,FinnGen
  • ,GBMI
  • ,HERMES
  • ,MVP
  • ,MyCode
  • ,PMB
  • ,UCLA
  • ,eMERGE
GWAS Catalog: GCST90455657
Europe PMC: 40195560
 63,835 individuals Hispanic or Latin American 11 cohorts
  • BBJ
  • ,BioMe
  • ,CKB
  • ,FinnGen
  • ,GBMI
  • ,HERMES
  • ,MVP
  • ,MyCode
  • ,PMB
  • ,UCLA
  • ,eMERGE
2,005,180 individuals European, Hispanic or Latin American, African American or Afro-Caribbean, South Asian, East Asian 14 cohorts
  • 2SISTER
  • ,AAAGC
  • ,BBJ
  • ,CHB
  • ,DBDS
  • ,FinnGen
  • ,G&H
  • ,GIANT
  • ,IHCS
  • ,MVP
  • ,NashBio
  • ,TWB
  • ,UKB
  • ,deCODE
GWAS Catalog: GCST90245990
Europe PMC: 36224396
 2,200,007 individuals European, Hispanic or Latin American, East Asian, African unspecified, South Asian Multiple
[
  • 243,392 cases
  • , 849,686 controls
]
 European, Hispanic or Latin American, African American or Afro-Caribbean, South Asian, East Asian BBJ, CARDIoGRAMplusC4D, MVP, UKB
GWAS Catalog: GCST90480706
Europe PMC: 39024449
 119,331 individuals African American or Afro-Caribbean MVP
GWAS Catalog: GCST90480706
Europe PMC: 39024449
 57,988 individuals Hispanic or Latin American MVP
GWAS Catalog: GCST90480706
Europe PMC: 39024449
 6,420 individuals East Asian MVP
GWAS Catalog: GCST90480706
Europe PMC: 39024449
 425,740 individuals European MVP
GWAS Catalog: GCST90435415
Europe PMC: 39134668
 404,507 individuals European UKB
[
  • 9,365 cases
  • , 946,368 controls
]
 European AUMC, FinnGen, MGBB, UKB
GWAS Catalog: GCST010321
Europe PMC: 32439900
 271,570 individuals European Multiple
GWAS Catalog: GCST010321
Europe PMC: 32439900
 8,173 individuals African American or Afro-Caribbean Multiple
GWAS Catalog: GCST010321
Europe PMC: 32439900
 12,823 individuals Hispanic or Latin American Multiple
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 4,775 cases
  • , 48,738 controls
]
 European AllofUs OMOP.Ids: 313217 and 314665 — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030618 PSS012204|
European Ancestry|
124,367 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.89
β: 0.635		 — R²: 0.11 age, sex and first 20 principal components Beta = log(OR)
PPM030636 PSS012211|
European Ancestry|
15,191 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 2.24
β: 0.807		 — R²: 0.143 age, sex and first 20 principal components Beta = log(OR)
PPM030639 PSS012212|
European Ancestry|
5,656 individuals
 PGP000788 |
Haydarlou P et al. Nat Commun (2026)
 Reported Trait: Atrial Fibrillation OR: 1.54
β: 0.429		 — R²: 0.052 age, sex and first 6 principal components Beta = log(OR)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012212 - —
[
  • 969 cases
  • , 4,687 controls
]
 — European
(Danish)		 — LOOP —
PSS012211 I48, I48.0, I48.1, I48.2, I48.3, I48.4, I48.9, 427.3. —
[
  • 341 cases
  • , 14,850 controls
]
 — European
(Norwegian)		 — HUNT —
PSS012204 OMOP.Ids: 313217 and 314665 —
[
  • 11,087 cases
  • , 113,280 controls
]
 — European — AllofUs —