Polygenic Score (PGS) ID: PGS012547

Predicted Trait
Reported Trait Type 2 diabetes mellitus
Mapped Trait(s) type 2 diabetes mellitus (MONDO_0005148)
Released in PGS Catalog: April 13, 2026
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Score Details

Score Construction
PGS Name EN_model_T2D
Development Method
Name Multi-trait PRS
Parameters NR
Variants
Original Genome Build hg19
Number of Variants 969,771
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000790
Citation (link to publication) Hu J et al. Genet Med (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
455,313 individuals (100%)
Score Development/Training
European: 100%
184,338 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 30297969
[
  • 55,005 cases
  • , 400,308 controls
]
 European NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 13,497 cases
  • , 170,841 controls
]
 European UKB — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030653 PSS012221|
European Ancestry|
122,892 individuals
 PGP000790 |
Hu J et al. Genet Med (2026)
 Reported Trait: Type 2 diabetes mellitus OR: 2.08 [2.03, 2.13] AUROC: 0.69 [0.68, 0.69] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012221 — —
[
  • 9,053 cases
  • , 113,839 controls
]
 — European — UKB —