PGS Publication: PGP000790

Publication Information (EuropePMC)
Title Leveraging pleiotropy to improve genetic risk prediction across diseases.
PubMed ID 41800596(Europe PMC)
doi 10.1016/j.gim.2026.102548
Publication Date March 5, 2026
Journal Genet Med
Author(s) Hu J, Zhou G, Zhao H, DeWan AT.
Released in PGS Catalog: April 13, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012540
(EN_model_Angina)
 PGP000790 |
Hu J et al. Genet Med (2026)
 Angina angina pectoris 969,769
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012540/ScoringFiles/PGS012540.txt.gz
PGS012541
(EN_model_Asthma)
 PGP000790 |
Hu J et al. Genet Med (2026)
 Asthma Asthma 969,763
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012541/ScoringFiles/PGS012541.txt.gz
PGS012543
(EN_model_CKD)
 PGP000790 |
Hu J et al. Genet Med (2026)
 Chronic kidney disease chronic kidney disease 969,768
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012543/ScoringFiles/PGS012543.txt.gz
PGS012544
(EN_model_HF)
 PGP000790 |
Hu J et al. Genet Med (2026)
 Heart failure heart failure 969,507
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012544/ScoringFiles/PGS012544.txt.gz
PGS012545
(EN_model_IS)
 PGP000790 |
Hu J et al. Genet Med (2026)
 Ischemic stroke Ischemic stroke 969,253
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012545/ScoringFiles/PGS012545.txt.gz
PGS012547
(EN_model_T2D)
 PGP000790 |
Hu J et al. Genet Med (2026)
 Type 2 diabetes mellitus type 2 diabetes mellitus 969,771
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012547/ScoringFiles/PGS012547.txt.gz
PGS012542
(EN_model_CAD)
 PGP000790 |
Hu J et al. Genet Med (2026)
 Coronary artery disease coronary artery disorder 969,769
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012542/ScoringFiles/PGS012542.txt.gz
PGS012546
(EN_model_PAD)
 PGP000790 |
Hu J et al. Genet Med (2026)
 Peripheral arterial disease peripheral arterial disease 969,771
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012546/ScoringFiles/PGS012546.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030646 PGS012540
(EN_model_Angina)
 PSS012222|
European Ancestry|
122,892 individuals
 PGP000790 |
Hu J et al. Genet Med (2026)
 Reported Trait: Angina OR: 1.71 [1.67, 1.75] AUROC: 0.64 [0.63, 0.64] — — —
PPM030647 PGS012541
(EN_model_Asthma)
 PSS012223|
European Ancestry|
122,892 individuals
 PGP000790 |
Hu J et al. Genet Med (2026)
 Reported Trait: Asthma OR: 1.4 [1.38, 1.42] AUROC: 0.59 [0.59, 0.6] — — —
PPM030648 PGS012542
(EN_model_CAD)
 PSS012216|
European Ancestry|
122,892 individuals
 PGP000790 |
Hu J et al. Genet Med (2026)
 Reported Trait: Coronary artery disease OR: 1.85 [1.81, 1.9] AUROC: 0.65 [0.65, 0.66] — — —
PPM030649 PGS012543
(EN_model_CKD)
 PSS012217|
European Ancestry|
122,892 individuals
 PGP000790 |
Hu J et al. Genet Med (2026)
 Reported Trait: Chronic kidney disease OR: 1.36 [1.33, 1.39] AUROC: 0.58 [0.57, 0.58] — — —
PPM030650 PGS012544
(EN_model_HF)
 PSS012218|
European Ancestry|
122,892 individuals
 PGP000790 |
Hu J et al. Genet Med (2026)
 Reported Trait: Heart failure OR: 1.55 [1.49, 1.62] AUROC: 0.62 [0.61, 0.63] — — —
PPM030651 PGS012545
(EN_model_IS)
 PSS012219|
European Ancestry|
122,892 individuals
 PGP000790 |
Hu J et al. Genet Med (2026)
 Reported Trait: Ischemic stroke OR: 1.49 [1.45, 1.53] AUROC: 0.6 [0.6, 0.61] — — —
PPM030652 PGS012546
(EN_model_PAD)
 PSS012220|
European Ancestry|
122,892 individuals
 PGP000790 |
Hu J et al. Genet Med (2026)
 Reported Trait: Peripheral arterial disease OR: 1.57 [1.51, 1.64] AUROC: 0.62 [0.61, 0.63] — — —
PPM030653 PGS012547
(EN_model_T2D)
 PSS012221|
European Ancestry|
122,892 individuals
 PGP000790 |
Hu J et al. Genet Med (2026)
 Reported Trait: Type 2 diabetes mellitus OR: 2.08 [2.03, 2.13] AUROC: 0.69 [0.68, 0.69] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012216 — —
[
  • 8,577 cases
  • , 114,315 controls
]
 — European — UKB —
PSS012217 — —
[
  • 8,919 cases
  • , 113,973 controls
]
 — European — UKB —
PSS012218 — —
[
  • 2,162 cases
  • , 120,730 controls
]
 — European — UKB —
PSS012219 — —
[
  • 5,882 cases
  • , 117,010 controls
]
 — European — UKB —
PSS012220 — —
[
  • 2,281 cases
  • , 120,611 controls
]
 — European — UKB —
PSS012221 — —
[
  • 9,053 cases
  • , 113,839 controls
]
 — European — UKB —
PSS012222 — —
[
  • 8,689 cases
  • , 114,203 controls
]
 — European — UKB —
PSS012223 — —
[
  • 17,218 cases
  • , 105,674 controls
]
 — European — UKB —