Polygenic Score (PGS) ID: PGS012548

Predicted Trait
Reported Trait Alzheimer's disease
Mapped Trait(s) Alzheimer disease (MONDO_0004975)
Released in PGS Catalog: April 13, 2026
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Score Details

Score Construction
PGS Name PRS94_AD
Development Method
Name Genome-wide significant SNPs
Parameters p <5E-08, r2 < 0.1
Variants
Original Genome Build NR
Number of Variants 94
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000791
Citation (link to publication) Li Y et al. J Gerontol A Biol Sci Med Sci (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
455,258 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007320
Europe PMC: 30617256
 455,258 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030654 PSS012224|
European Ancestry|
345,439 individuals
 PGP000791 |
Li Y et al. J Gerontol A Biol Sci Med Sci (2024)
 Reported Trait: All-cause dementia — — Hazard ratio (HR, high vs low tertile): 2.94 [2.68, 3.23] age (5 years categories), sex, recruitment assessment center, genotyping array, first 10 principal components of ancestry, polysocial risk score —
PPM030655 PSS012224|
European Ancestry|
345,439 individuals
 PGP000791 |
Li Y et al. J Gerontol A Biol Sci Med Sci (2024)
 Reported Trait: Alzheimer's disease — — Hazard ratio (HR, high vs low tertile): 4.71 [4.03, 5.5] age (5 years categories), sex, recruitment assessment center, genotyping array, first 10 principal components of ancestry, polysocial risk score —
PPM030656 PSS012224|
European Ancestry|
345,439 individuals
 PGP000791 |
Li Y et al. J Gerontol A Biol Sci Med Sci (2024)
 Reported Trait: Vascular dementia — — Hazard ratio (HR, high vs low tertile): 2.93 [2.4, 3.58] age (5 years categories), sex, recruitment assessment center, genotyping array, first 10 principal components of ancestry, polysocial risk score —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012224 — Median = 12.5 years 345,439 individuals,
47.6 % Male samples
 Mean = 56.4 years
Sd = 8.0 years		 European — UKB —