PGS Publication: PGP000791

Publication Information (EuropePMC)
Title Polysocial and Polygenic Risk Scores and All-Cause Dementia, Alzheimer's Disease, and Vascular Dementia.
PubMed ID 37966923(Europe PMC)
doi 10.1093/gerona/glad262
Publication Date March 1, 2024
Journal J Gerontol A Biol Sci Med Sci
Author(s) Li Y, Zeng Z, Zhuang Z, Zhao Y, Zhang L, Wang W, Song Z, Dong X, Xiao W, Huang N, Jia J, Liu Z, Qi L, Huang T.
Released in PGS Catalog: April 13, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012548
(PRS94_AD)
 PGP000791 |
Li Y et al. J Gerontol A Biol Sci Med Sci (2024)
 Alzheimer's disease Alzheimer disease 94
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012548/ScoringFiles/PGS012548.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030654 PGS012548
(PRS94_AD)
 PSS012224|
European Ancestry|
345,439 individuals
 PGP000791 |
Li Y et al. J Gerontol A Biol Sci Med Sci (2024)
 Reported Trait: All-cause dementia — — Hazard ratio (HR, high vs low tertile): 2.94 [2.68, 3.23] age (5 years categories), sex, recruitment assessment center, genotyping array, first 10 principal components of ancestry, polysocial risk score —
PPM030655 PGS012548
(PRS94_AD)
 PSS012224|
European Ancestry|
345,439 individuals
 PGP000791 |
Li Y et al. J Gerontol A Biol Sci Med Sci (2024)
 Reported Trait: Alzheimer's disease — — Hazard ratio (HR, high vs low tertile): 4.71 [4.03, 5.5] age (5 years categories), sex, recruitment assessment center, genotyping array, first 10 principal components of ancestry, polysocial risk score —
PPM030656 PGS012548
(PRS94_AD)
 PSS012224|
European Ancestry|
345,439 individuals
 PGP000791 |
Li Y et al. J Gerontol A Biol Sci Med Sci (2024)
 Reported Trait: Vascular dementia — — Hazard ratio (HR, high vs low tertile): 2.93 [2.4, 3.58] age (5 years categories), sex, recruitment assessment center, genotyping array, first 10 principal components of ancestry, polysocial risk score —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012224 — Median = 12.5 years 345,439 individuals,
47.6 % Male samples
 Mean = 56.4 years
Sd = 8.0 years		 European — UKB —