Polygenic Score (PGS) ID: PGS012549

Predicted Trait
Reported Trait Nonalcoholic fatty liver disease
Mapped Trait(s) metabolic dysfunction-associated steatotic liver disease (MONDO_0013209)
Released in PGS Catalog: April 13, 2026
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Score Details

Score Construction
PGS Name PRS10_NAFLD
Development Method
Name Genome-wide significant SNPs
Parameters MAF> 0.05
Variants
Original Genome Build NR
Number of Variants 10
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000792
Citation (link to publication) Tang L et al. BMC Med (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
19,264 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Additional Asian Ancestries
  • African
  • East Asian
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90011885
Europe PMC: 32298765
 19,264 individuals European The "European NAFLD Registry" Metacohort

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030658 PSS012225|
Multi-ancestry (including European)|
465,032 individuals
 PGP000792 |
Tang L et al. BMC Med (2023)
 Reported Trait: Nonalcoholic fatty liver disease x telomere length interaction — — Hazard ratio (HR, high telomere length tertile and high PRS vs. low telomere length tertile and low PRS): 1.99 [1.74, 2.27] age, gender, ethnicity, Townsend deprivation index, BMI, cholesterol, hypertension, diabetes, lifestyle, air pollution score, the top 10 genetic principal components, and genotyping batch —
PPM030657 PSS012225|
Multi-ancestry (including European)|
465,032 individuals
 PGP000792 |
Tang L et al. BMC Med (2023)
 Reported Trait: Nonalcoholic fatty liver disease HR: 1.23 [1.2, 1.27] — — age, gender, ethnicity, Townsend deprivation index, BMI, cholesterol, hypertension, diabetes, lifestyle, air pollution score, the top 10 genetic principal components, and genotyping batch —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012225 — —
[
  • 178 cases
  • , 16,114 controls
]
 — Asian unspecified — UKB —
PSS012225 — —
[
  • 35 cases
  • , 2,595 controls
]
 — African American or Afro-Caribbean
(Black)		 — UKB —
PSS012225 — —
[
  • 12 cases
  • , 1,419 controls
]
 — East Asian
(Chinese)		 — UKB —
PSS012225 — —
[
  • 262 cases
  • , 21,014 controls
]
 — Not reported — UKB —
PSS012225 — —
[
  • 4,809 cases
  • , 4,283 controls
]
 — European — UKB —