PGS Publication: PGP000792

Publication Information (EuropePMC)
Title The association between telomere length and non-alcoholic fatty liver disease: a prospective study.
PubMed ID 37940980(Europe PMC)
doi 10.1186/s12916-023-03136-7
Publication Date Nov. 9, 2023
Journal BMC Med
Author(s) Tang L, Li D, Ma Y, Cui F, Wang J, Tian Y.
Released in PGS Catalog: April 13, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012549
(PRS10_NAFLD)
 PGP000792 |
Tang L et al. BMC Med (2023)
 Nonalcoholic fatty liver disease metabolic dysfunction-associated steatotic liver disease 10
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012549/ScoringFiles/PGS012549.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030658 PGS012549
(PRS10_NAFLD)
 PSS012225|
Multi-ancestry (including European)|
465,032 individuals
 PGP000792 |
Tang L et al. BMC Med (2023)
 Reported Trait: Nonalcoholic fatty liver disease x telomere length interaction — — Hazard ratio (HR, high telomere length tertile and high PRS vs. low telomere length tertile and low PRS): 1.99 [1.74, 2.27] age, gender, ethnicity, Townsend deprivation index, BMI, cholesterol, hypertension, diabetes, lifestyle, air pollution score, the top 10 genetic principal components, and genotyping batch —
PPM030657 PGS012549
(PRS10_NAFLD)
 PSS012225|
Multi-ancestry (including European)|
465,032 individuals
 PGP000792 |
Tang L et al. BMC Med (2023)
 Reported Trait: Nonalcoholic fatty liver disease HR: 1.23 [1.2, 1.27] — — age, gender, ethnicity, Townsend deprivation index, BMI, cholesterol, hypertension, diabetes, lifestyle, air pollution score, the top 10 genetic principal components, and genotyping batch —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012225 — —
[
  • 178 cases
  • , 16,114 controls
]
 — Asian unspecified — UKB —
PSS012225 — —
[
  • 35 cases
  • , 2,595 controls
]
 — African American or Afro-Caribbean
(Black)		 — UKB —
PSS012225 — —
[
  • 12 cases
  • , 1,419 controls
]
 — East Asian
(Chinese)		 — UKB —
PSS012225 — —
[
  • 262 cases
  • , 21,014 controls
]
 — Not reported — UKB —
PSS012225 — —
[
  • 4,809 cases
  • , 4,283 controls
]
 — European — UKB —