Polygenic Score (PGS) ID: PGS012553

Predicted Trait
Reported Trait Bladder cancer
Mapped Trait(s) urinary bladder carcinoma (MONDO_0004986)
Released in PGS Catalog: April 13, 2026
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Score Details

Score Construction
PGS Name PRS24_BC
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 24
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000796
Citation (link to publication) Koutros S et al. Eur Urol (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
356,027 individuals (100%)
PGS Evaluation
European: 100%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90296729
[
  • 13,447 cases
  • , 342,580 controls
]
 European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030669 PSS012231|
European Ancestry|
41,261 individuals
 PGP000796 |
Koutros S et al. Eur Urol (2023)
 Reported Trait: Bladder cancer HR: 1.51 [1.38, 1.65] — — — —
PPM030670 PSS012232|
European Ancestry|
222,139 individuals
 PGP000796 |
Koutros S et al. Eur Urol (2023)
 Reported Trait: Bladder cancer HR: 1.32 [1.21, 1.44] — — — —
PPM030707 PSS012259|
European Ancestry|
390,678 individuals
 PGP000806 |
Pradhan P et al. Int J Cancer (2023)
|Ext.		 Reported Trait: Bladder cancer — — Hazard ratio (HR, high vs low PGS tertile): 1.74 [1.46, 2.08] Sex, education 23 of 24 variants analysed (rs36209093 excluded)
PPM030708 PSS012259|
European Ancestry|
390,678 individuals
 PGP000806 |
Pradhan P et al. Int J Cancer (2023)
|Ext.		 Reported Trait: Bladder cancer — — Hazard ratio (HR, current smoker and PGS in highest tertile vs never smoker and PGS in lowest tertile): 6.45 [4.51, 9.24] Sex, education, income, genotype array, 5 PCs 23 of 24 variants analysed (rs36209093 excluded)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012232 — —
[
  • 487 cases
  • , 221,652 controls
]
 — European — UKB —
PSS012259 — —
[
  • 769 cases
  • , 389,909 controls
]
,
47.0 % Male samples
 Mean = 56.6 years European — UKB —
PSS012231 — —
[
  • 522 cases
  • , 40,739 controls
]
 — European — PLCO —