Polygenic Score (PGS) ID: PGS012554

Predicted Trait
Reported Trait Type 2 diabetes (T2D)
Mapped Trait(s) type 2 diabetes mellitus (MONDO_0005148)
Released in PGS Catalog: April 13, 2026
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Score Details

Score Construction
PGS Name GRS_T2D
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 424
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000797
Citation (link to publication) Yang R et al. BMC Med (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
1,114,458 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST010555
Europe PMC: 32541925
 1,114,458 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030671 PSS012233|
European Ancestry|
126,203 individuals
 PGP000797 |
Yang R et al. BMC Med (2023)
 Reported Trait: T2D in the normoglycemia HR: 1.54 [1.49, 1.59] — — age, sex, education, Townsend deprivation index, energy intake, smoking, physical activity, antidiabetic drug, body mass index, inflammatory diet index, hypertension, cardiovascular disease, the first 10 principal components of ancestry, and genotyping batch —
PPM030672 PSS012234|
European Ancestry|
16,068 individuals
 PGP000797 |
Yang R et al. BMC Med (2023)
 Reported Trait: T2D in the prediabetes HR: 1.28 [1.23, 1.33] — — age, sex, education, Townsend deprivation index, energy intake, smoking, physical activity, antidiabetic drug, body mass index, inflammatory diet index, hypertension, cardiovascular disease, the first 10 principal components of ancestry, and genotyping batch —
PPM030673 PSS012233|
European Ancestry|
126,203 individuals
 PGP000797 |
Yang R et al. BMC Med (2023)
 Reported Trait: T2D in the normoglycemia x Inflammatory diet index interaction — — Hazard ratio (HR, moderate/high Inflammatory diet index and moderate/high PRS vs. low nflammatory diet index and low PRS): 2.86 [2.51, 3.26] age, sex, education, Townsend deprivation index, energy intake, smoking, physical activity, body mass index, hypertension, cardiovascular disease, antidiabetic drug, the first 10 principal components of ancestry, and genotyping batch —
PPM030674 PSS012234|
European Ancestry|
16,068 individuals
 PGP000797 |
Yang R et al. BMC Med (2023)
 Reported Trait: T2D in the prediabetes x Inflammatory diet index interaction — — Hazard ratio (HR, moderate/high Inflammatory diet index and moderate/high PRS vs. low nflammatory diet index and low PRS): 1.82 [1.59, 2.07] age, sex, education, Townsend deprivation index, energy intake, smoking, physical activity, body mass index, hypertension, cardiovascular disease, antidiabetic drug, the first 10 principal components of ancestry, and genotyping batch —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012233 — —
[
  • 3,348 cases
  • , 122,855 controls
]
 — European — UKB —
PSS012234 — —
[
  • 2,496 cases
  • , 13,572 controls
]
 — European — UKB —