PGS Publication: PGP000797

Publication Information (EuropePMC)
Title A low-inflammatory diet is associated with a lower incidence of diabetes: role of diabetes-related genetic risk.
PubMed ID 38049803(Europe PMC)
doi 10.1186/s12916-023-03190-1
Publication Date Dec. 5, 2023
Journal BMC Med
Author(s) Yang R, Lin J, Yang H, Dunk MM, Wang J, Xu W, Wang Y.
Released in PGS Catalog: April 13, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012554
(GRS_T2D)
 PGP000797 |
Yang R et al. BMC Med (2023)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 424
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012554/ScoringFiles/PGS012554.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030671 PGS012554
(GRS_T2D)
 PSS012233|
European Ancestry|
126,203 individuals
 PGP000797 |
Yang R et al. BMC Med (2023)
 Reported Trait: T2D in the normoglycemia HR: 1.54 [1.49, 1.59] — — age, sex, education, Townsend deprivation index, energy intake, smoking, physical activity, antidiabetic drug, body mass index, inflammatory diet index, hypertension, cardiovascular disease, the first 10 principal components of ancestry, and genotyping batch —
PPM030672 PGS012554
(GRS_T2D)
 PSS012234|
European Ancestry|
16,068 individuals
 PGP000797 |
Yang R et al. BMC Med (2023)
 Reported Trait: T2D in the prediabetes HR: 1.28 [1.23, 1.33] — — age, sex, education, Townsend deprivation index, energy intake, smoking, physical activity, antidiabetic drug, body mass index, inflammatory diet index, hypertension, cardiovascular disease, the first 10 principal components of ancestry, and genotyping batch —
PPM030673 PGS012554
(GRS_T2D)
 PSS012233|
European Ancestry|
126,203 individuals
 PGP000797 |
Yang R et al. BMC Med (2023)
 Reported Trait: T2D in the normoglycemia x Inflammatory diet index interaction — — Hazard ratio (HR, moderate/high Inflammatory diet index and moderate/high PRS vs. low nflammatory diet index and low PRS): 2.86 [2.51, 3.26] age, sex, education, Townsend deprivation index, energy intake, smoking, physical activity, body mass index, hypertension, cardiovascular disease, antidiabetic drug, the first 10 principal components of ancestry, and genotyping batch —
PPM030674 PGS012554
(GRS_T2D)
 PSS012234|
European Ancestry|
16,068 individuals
 PGP000797 |
Yang R et al. BMC Med (2023)
 Reported Trait: T2D in the prediabetes x Inflammatory diet index interaction — — Hazard ratio (HR, moderate/high Inflammatory diet index and moderate/high PRS vs. low nflammatory diet index and low PRS): 1.82 [1.59, 2.07] age, sex, education, Townsend deprivation index, energy intake, smoking, physical activity, body mass index, hypertension, cardiovascular disease, antidiabetic drug, the first 10 principal components of ancestry, and genotyping batch —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012233 — —
[
  • 3,348 cases
  • , 122,855 controls
]
 — European — UKB —
PSS012234 — —
[
  • 2,496 cases
  • , 13,572 controls
]
 — European — UKB —