Polygenic Score (PGS) ID: PGS012557

Predicted Trait
Reported Trait Body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: June 17, 2026
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name BMI_AFR_MIXPRSplus
Development Method
Name MIXPRS, JointPRS, SDPRX, SBayesRC, ClinicalPRS
Parameters no tuning parameters
Variants
Original Genome Build GRCh37
Number of Variants 827,738
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000799
Citation (link to publication) Xu L et al. Nat Genet (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 53%
East Asian: 35.4%
Hispanic or Latin American: 5.2%
African: 4%
Multi-ancestry (excluding European): 1%
  • East Asian
  • Additional Asian Ancestries
Additional Diverse Ancestries: 1%
Not Reported: 0.2%
446,563 individuals (100%)
PGS Evaluation
African: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST002783
Europe PMC: 25673413
 1,276 individuals Hispanic or Latin American NR
GWAS Catalog: GCST002783
Europe PMC: 25673413
 236,781 individuals European NR
GWAS Catalog: GCST002783
Europe PMC: 25673413
 887 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST004904
Europe PMC: 28892062
 158,284 individuals East Asian NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 21,955 individuals Hispanic or Latin American NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 17,127 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 3,936 individuals Oceanian NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 645 individuals Native American NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 4,647 individuals East Asian, Asian unspecified NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 1,025 individuals Not reported NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030686 PSS012245|
African Ancestry|
6,713 individuals
 PGP000799 |
Xu L et al. Nat Genet (2026)
 Reported Trait: Body mass index; Obesity (BMI >= 30 in AFR) — — R2 (removing covariates): 0.073 age, sex, 20 genetic PCs R2 = 1 - SS(full) / SS(null), where SS(null) and SS(full) denote residual sums of squares from the null model (including age, sex, and the top 20 genetic PCs) and the full model (additionally including PRS), respectively.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012245 Field 21001 — 6,713 individuals — African unspecified — UKB —