PGS Publication: PGP000799

Publication Information (EuropePMC)
Title MIXPRS enables multi-population and multi-method polygenic risk scores using summary statistics.
PubMed ID 42265311(Europe PMC)
doi 10.1038/s41588-026-02637-4
Publication Date June 9, 2026
Journal Nat Genet
Author(s) Xu L, Dong Y, Zeng X, Bian Z, Zhou G, Guan L, Zhao H.
Released in PGS Catalog: June 17, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012556
(BMI_EAS_MIXPRSplus)
 PGP000799 |
Xu L et al. Nat Genet (2026)
 Body mass index (BMI) body mass index 782,322
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012556/ScoringFiles/PGS012556.txt.gz
PGS012557
(BMI_AFR_MIXPRSplus)
 PGP000799 |
Xu L et al. Nat Genet (2026)
 Body mass index (BMI) body mass index 827,738
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012557/ScoringFiles/PGS012557.txt.gz
PGS012558
(CAD_EAS_MIXPRSplus)
 PGP000799 |
Xu L et al. Nat Genet (2026)
 Coronary artery disease coronary artery disorder 786,215
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012558/ScoringFiles/PGS012558.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030686 PGS012557
(BMI_AFR_MIXPRSplus)
 PSS012245|
African Ancestry|
6,713 individuals
 PGP000799 |
Xu L et al. Nat Genet (2026)
 Reported Trait: Body mass index; Obesity (BMI >= 30 in AFR) — — R2 (removing covariates): 0.073 age, sex, 20 genetic PCs R2 = 1 - SS(full) / SS(null), where SS(null) and SS(full) denote residual sums of squares from the null model (including age, sex, and the top 20 genetic PCs) and the full model (additionally including PRS), respectively.
PPM030687 PGS012558
(CAD_EAS_MIXPRSplus)
 PSS012247|
East Asian Ancestry|
2,090 individuals
 PGP000799 |
Xu L et al. Nat Genet (2026)
 Reported Trait: Coronary artery disease OR: 1.751 AUROC: 0.669 — — —
PPM030685 PGS012556
(BMI_EAS_MIXPRSplus)
 PSS012246|
East Asian Ancestry|
2,077 individuals
 PGP000799 |
Xu L et al. Nat Genet (2026)
 Reported Trait: Body mass index — — R2 (removing covariates): 0.122 age, sex, 20 genetic PCs R2 = 1 - SS(full) / SS(null), where SS(null) and SS(full) denote residual sums of squares from the null model (including age, sex, and the top 20 genetic PCs) and the full model (additionally including PRS), respectively.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012245 Field 21001 — 6,713 individuals — African unspecified — UKB —
PSS012246 Field 21001 — 2,077 individuals — East Asian — UKB —
PSS012247 Self-report disease: 1075; ICD9: 4109, 4119, 4129, 4299; ICD10: I21-I23, I24.1, I25.2 —
[
  • 56 cases
  • , 2,034 controls
]
 — East Asian — UKB —