Polygenic Score (PGS) ID: PGS012558

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disorder (MONDO_0005010)
Released in PGS Catalog: June 17, 2026
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name CAD_EAS_MIXPRSplus
Development Method
Name MIXPRS, JointPRS, SDPRX, SBayesRC, ClinicalPRS
Parameters no tuning parameters
Variants
Original Genome Build GRCh37
Number of Variants 786,215
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000799
Citation (link to publication) Xu L et al. Nat Genet (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 70.9%
European: 29.1%
299,448 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST000998
Europe PMC: 21378990
 86,995 individuals European NR
GWAS Catalog: GCST90013687
Europe PMC: 32514122
 212,453 individuals East Asian BBJ

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030687 PSS012247|
East Asian Ancestry|
2,090 individuals
 PGP000799 |
Xu L et al. Nat Genet (2026)
 Reported Trait: Coronary artery disease OR: 1.751 AUROC: 0.669 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012247 Self-report disease: 1075; ICD9: 4109, 4119, 4129, 4299; ICD10: I21-I23, I24.1, I25.2 —
[
  • 56 cases
  • , 2,034 controls
]
 — East Asian — UKB —