Polygenic Score (PGS) ID: PGS012574

Predicted Trait
Reported Trait Gestational duration
Mapped Trait(s) gestational age (EFO_0005112)
Additional Trait Information GWAS for nulliparity women
Released in PGS Catalog: June 17, 2026
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name gestational_duration_nulliparity
Development Method
Name PRS-CS
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 1,030,624
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000810
Citation (link to publication) Ytterberg K et al. medRxiv (2025) Preprint
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
24,284 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90824127
 24,284 individuals,
0.0 % Male samples
 European MOBA

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030721 PSS012265|
European Ancestry|
2,855 individuals
 PGP000810 |
Ytterberg K et al. medRxiv (2025)
|Pre		 Reported Trait: Gestational duration (nulliparity) β: 4.26475 — R²: 0.01267 maternal age, fetal sex, 10 PCs —
PPM030722 PSS012265|
European Ancestry|
2,855 individuals
 PGP000810 |
Ytterberg K et al. medRxiv (2025)
|Pre		 Reported Trait: Gestational duration (multiparous) β: 1.89355 — R²: 0.00806 maternal age, fetal sex, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012265 — — 2,855 individuals,
0.0 % Male samples
 — European — ALSPAC Analyses were restricted to singleton pregnancies with live-born infants surviving to one year of age. We excluded pregnancies with stillbirth, known fetal complications, or conception via in vitro fertilisation, as well as pregnancies delivered following induction of labour or caesarean section.