PGS Preprint: PGP000810

Publication Information (EuropePMC)
Title Parity modifies the effect of genetic variants associated with gestational duration and birth weight
doi 10.1101/2025.06.17.25329777
Publication Date June 17, 2025
Journal medRxiv Preprint
Author(s) Ytterberg K, Sundelin H, Juodakis J, Vaudel M, Corfield EC, Andreassen OA, Magnus P, Havdahl A, Nilsson S, Njolstad PR, Johansson S, Jacobsson B, Solé-Navais P.
Released in PGS Catalog: June 17, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012573
(gestational_duration_allparity)
 PGP000810 |
Ytterberg K et al. medRxiv (2025)
|Pre		 Gestational duration gestational age 1,030,658
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012573/ScoringFiles/PGS012573.txt.gz
PGS012574
(gestational_duration_nulliparity)
 PGP000810 |
Ytterberg K et al. medRxiv (2025)
|Pre		 Gestational duration gestational age 1,030,624
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012574/ScoringFiles/PGS012574.txt.gz
PGS012575
(gestational_duration_multiparous)
 PGP000810 |
Ytterberg K et al. medRxiv (2025)
|Pre		 Gestational duration gestational age 1,030,639
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012575/ScoringFiles/PGS012575.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030721 PGS012574
(gestational_duration_nulliparity)
 PSS012265|
European Ancestry|
2,855 individuals
 PGP000810 |
Ytterberg K et al. medRxiv (2025)
|Pre		 Reported Trait: Gestational duration (nulliparity) β: 4.26475 — R²: 0.01267 maternal age, fetal sex, 10 PCs —
PPM030722 PGS012574
(gestational_duration_nulliparity)
 PSS012265|
European Ancestry|
2,855 individuals
 PGP000810 |
Ytterberg K et al. medRxiv (2025)
|Pre		 Reported Trait: Gestational duration (multiparous) β: 1.89355 — R²: 0.00806 maternal age, fetal sex, 10 PCs —
PPM030723 PGS012575
(gestational_duration_multiparous)
 PSS012264|
European Ancestry|
3,468 individuals
 PGP000810 |
Ytterberg K et al. medRxiv (2025)
|Pre		 Reported Trait: Gestational duration (nulliparity) β: 3.31039 — R²: 0.0071 maternal age, fetal sex, 10 PCs —
PPM030724 PGS012575
(gestational_duration_multiparous)
 PSS012264|
European Ancestry|
3,468 individuals
 PGP000810 |
Ytterberg K et al. medRxiv (2025)
|Pre		 Reported Trait: Gestational duration (multiparous) β: 1.70524 — R²: 0.00705 maternal age, fetal sex, 10 PCs —
PPM030720 PGS012573
(gestational_duration_allparity)
 PSS012263|
European Ancestry|
6,281 individuals
 PGP000810 |
Ytterberg K et al. medRxiv (2025)
|Pre		 Reported Trait: Gestational duration (allparity) β: 8.01173 — R²: 0.01907 maternal age, fetal sex, parity, 10 PCs, PGS*parity, PGS_fetal*parity PGS_fetal: fetal PGS estimated by maternal genome

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012263 — — 6,281 individuals,
0.0 % Male samples
 — European — ALSPAC Analyses were restricted to singleton pregnancies with live-born infants surviving to one year of age. We excluded pregnancies with stillbirth, known fetal complications, or conception via in vitro fertilisation, as well as pregnancies delivered following induction of labour or caesarean section.
PSS012264 — — 3,468 individuals,
0.0 % Male samples
 — European — ALSPAC Analyses were restricted to singleton pregnancies with live-born infants surviving to one year of age. We excluded pregnancies with stillbirth, known fetal complications, or conception via in vitro fertilisation, as well as pregnancies delivered following induction of labour or caesarean section.
PSS012265 — — 2,855 individuals,
0.0 % Male samples
 — European — ALSPAC Analyses were restricted to singleton pregnancies with live-born infants surviving to one year of age. We excluded pregnancies with stillbirth, known fetal complications, or conception via in vitro fertilisation, as well as pregnancies delivered following induction of labour or caesarean section.